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Gene: Ptgs1 (prostaglandin-endoperoxide synthase 1) Rattus norvegicus
Symbol: Ptgs1
Name: prostaglandin-endoperoxide synthase 1
Description: Predicted to have prostaglandin-endoperoxide synthase activity. Involved in several processes, including learning or memory; negative regulation of catecholamine secretion; and regulation of blood vessel diameter. Localizes to cytoplasm and nuclear envelope. Used to study Alzheimer's disease; hepatic encephalopathy; renovascular hypertension; and ulcerative colitis. Biomarker of esophagus adenocarcinoma; glioblastoma multiforme; gliosarcoma; polycystic kidney disease; and renal cell carcinoma. Orthologous to human PTGS1 (prostaglandin-endoperoxide synthase 1); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; INTERACTS WITH 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: COX-1; Cox-3; Cox1; Cox3; cyclooxygenase 1; cyclooxygenase 3; cyclooxygenase-1; PGH synthase 1; PGHS-1; PHS 1; prostaglandin G/H synthase 1; prostaglandin G/H synthase and cyclooxygenase; prostaglandin H2 synthase 1; prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
Homo sapiens (human) : PTGS1 (prostaglandin-endoperoxide synthase 1)  HGNC  Alliance
Mus musculus (house mouse) : Ptgs1 (prostaglandin-endoperoxide synthase 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ptgs1 (prostaglandin-endoperoxide synthase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PTGS1 (prostaglandin-endoperoxide synthase 1)
Canis lupus familiaris (dog) : PTGS1 (prostaglandin-endoperoxide synthase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ptgs1 (prostaglandin-endoperoxide synthase 1)
Sus scrofa (pig) : PTGS1 (prostaglandin-endoperoxide synthase 1)
Chlorocebus sabaeus (African green monkey) : PTGS1 (prostaglandin-endoperoxide synthase 1)
Heterocephalus glaber (naked mole-rat) : Ptgs1 (prostaglandin-endoperoxide synthase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0315,560,685 - 15,582,339 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl315,560,712 - 15,582,344 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0320,869,915 - 20,891,512 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4315,343,832 - 15,365,412 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1315,240,203 - 15,261,784 (+)NCBI
Celera314,295,836 - 14,317,392 (+)NCBICelera
Cytogenetic Map3p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Ptgs1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3439
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.