Gene: Ptgs1 (prostaglandin-endoperoxide synthase 1) Rattus norvegicus
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Symbol: Ptgs1
Name: prostaglandin-endoperoxide synthase 1
Description: Predicted to have prostaglandin-endoperoxide synthase activity; involved in several processes, including learning or memory, negative regulation of transport, and regulation of blood vessel diameter; localizes to the cytoplasm and nuclear envelope; used to study Alzheimer's disease, hepatic encephalopathy, and renovascular hypertension; biomarker of esophagus adenocarcinoma, glioblastoma multiforme, gliosarcoma, polycystic kidney disease, and renal cell carcinoma; orthologous to human PTGS1 (prostaglandin-endoperoxide synthase 1); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; INTERACTS WITH 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: COX-1; Cox-3; Cox1; Cox3; cyclooxygenase 1; cyclooxygenase 3; cyclooxygenase-1; PGH synthase 1; PGHS-1; PHS 1; prostaglandin G/H synthase 1; prostaglandin G/H synthase and cyclooxygenase; prostaglandin H2 synthase 1; prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
Orthologs:
Homo sapiens (human) : PTGS1 (prostaglandin-endoperoxide synthase 1)  HGNC  Alliance
Mus musculus (house mouse) : Ptgs1 (prostaglandin-endoperoxide synthase 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ptgs1 (prostaglandin-endoperoxide synthase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PTGS1 (prostaglandin-endoperoxide synthase 1)
Canis lupus familiaris (dog) : PTGS1 (prostaglandin-endoperoxide synthase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ptgs1 (prostaglandin-endoperoxide synthase 1)
Sus scrofa (pig) : PTGS1 (prostaglandin-endoperoxide synthase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0315,560,685 - 15,582,339 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0320,869,915 - 20,891,512 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4315,343,832 - 15,365,412 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1315,240,203 - 15,261,784 (+)NCBI
Celera314,295,836 - 14,317,392 (+)NCBICelera
Cytogenetic Map3p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
 
More on Ptgs1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3439
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.