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Gene: Pth1r (parathyroid hormone 1 receptor) Rattus norvegicus
Symbol: Pth1r
Name: parathyroid hormone 1 receptor
CRRD ID: 3442
Description: Exhibits parathyroid hormone receptor activity and peptide hormone binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; positive regulation of cytosolic calcium ion concentration; and positive regulation of inositol phosphate biosynthetic process. Localizes to several cellular components, including apical plasma membrane; basolateral plasma membrane; and brush border membrane. Used to study hypercalcemia. Human ortholog(s) of this gene implicated in Eiken syndrome; Jansen's metaphyseal chondrodysplasia; chondrodysplasia Blomstrand type; osteochondrodysplasia; and primary failure of tooth eruption. Orthologous to human PTH1R (parathyroid hormone 1 receptor); PARTICIPATES IN G protein mediated signaling pathway via Galphaq family; parathyroid hormone signaling pathway; G protein mediated signaling pathway via Galphas family; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
Also known as: parathyroid hormone receptor; parathyroid hormone receptor 1; Parathyroid hormone/parathyroid hormone-related peptide receptor; PTH/PTHr receptor; PTH/PTHrP type I receptor; PTH1 receptor; Pthr; Pthr1; PTHrel
Homo sapiens (human) : PTH1R (parathyroid hormone 1 receptor)  HGNC  Alliance
Mus musculus (house mouse) : Pth1r (parathyroid hormone 1 receptor)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pth1r (parathyroid hormone 1 receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : PTH1R (parathyroid hormone 1 receptor)
Canis lupus familiaris (dog) : PTH1R (parathyroid hormone 1 receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pth1r (parathyroid hormone 1 receptor)
Sus scrofa (pig) : PTH1R (parathyroid hormone 1 receptor)
Chlorocebus sabaeus (African green monkey) : PTH1R (parathyroid hormone 1 receptor)
Heterocephalus glaber (naked mole-rat) : Pth1r (parathyroid hormone 1 receptor)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.08118,984,531 - 119,012,803 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8118,988,053 - 119,012,671 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08118,325,190 - 118,353,210 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48115,099,763 - 115,119,362 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18115,119,118 - 115,139,954 (-)NCBI
Celera8109,981,641 - 110,001,215 (-)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Pth1r
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3442
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.