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Gene: Ptpn5 (protein tyrosine phosphatase, non-receptor type 5) Rattus norvegicus
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Symbol: Ptpn5
Name: protein tyrosine phosphatase, non-receptor type 5
Description: Exhibits several functions, including mitogen-activated protein kinase binding activity; protein homodimerization activity; and protein tyrosine phosphatase activity. Involved in several processes, including aging; positive regulation of cellular component organization; and regulation of protein phosphorylation. Localizes to several cellular components, including the cytoplasm; neuron projection; and perikaryon. Used to study transient cerebral ischemia. Biomarker of transient cerebral ischemia. Orthologous to human PTPN5 (protein tyrosine phosphatase non-receptor type 5); PARTICIPATES IN dopamine signaling pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH (-)-anisomycin; 2,2',5,5'-tetrachlorobiphenyl; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: neural-specific protein-tyrosine phosphatase; protein-tyrosine phosphatase striatum-enriched; protein-tyrosine-phosphatase non-receptor 5; STEP; striatum-enriched protein-tyrosine phosphatase; tyrosine-protein phosphatase non-receptor type 5
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01103,197,918 - 103,258,309 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01104,263,139 - 104,321,833 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4197,629,192 - 97,643,225 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1197,707,302 - 97,721,336 (-)NCBI
Celera191,865,125 - 91,880,882 (-)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Ptpn5
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3448
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.