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Gene: Sirpa (signal-regulatory protein alpha) Rattus norvegicus
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Symbol: Sirpa
Name: signal-regulatory protein alpha
Description: Exhibits GTPase regulator activity; enzyme binding activity; and protein binding activity involved in heterotypic cell-cell adhesion. Involved in several processes, including cellular response to cytokine stimulus; cellular response to hydrogen peroxide; and monocyte extravasation. Localizes to the cell surface. Orthologous to several human genes including SIRPA (signal regulatory protein alpha); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Bit; brain Ig-like molecule with tyrosine-based activation motifs; Brain immunoglobulin like protein with tyrosine - based activation motifs; CD172 antigen-like family member A; inhibitory receptor SHPS-1; macrophage fusion receptor; macrophage membrane protein MFP150; protein tyrosine phosphatase non-receptor type substrate 1; Protein tyrosine phosphatase non-receptor type substrate 1 (SHP substrate 1); protein tyrosine phosphatase, non-receptor type substrate 1; Protein tyrosine phosphatase, non-receptor type substrate 1 (SHP substrate 1); Ptpns1; SHP substrate 1; SHPS-1; signal-regulatory protein alpha-1; sirp-alpha-1; tyrosine-protein phosphatase non-receptor type substrate 1
Orthologs:
Homo sapiens (human) : SIRPA (signal regulatory protein alpha)  HGNC  Alliance
Mus musculus (house mouse) : Sirpa (signal-regulatory protein alpha)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sirpa (signal regulatory protein alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : SIRPA (signal regulatory protein alpha)
Canis lupus familiaris (dog) : SIRPA (signal regulatory protein alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sirpa (signal regulatory protein alpha)
Sus scrofa (pig) : SIRPA (signal regulatory protein alpha)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.03122,113,735 - 122,152,478 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3122,114,108 - 122,152,477 (+)Ensembl
Rnor_5.03127,864,145 - 127,902,598 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43117,210,116 - 117,247,840 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13117,115,688 - 117,153,412 (+)NCBI
Celera3115,635,887 - 115,673,609 (+)NCBICelera
Cytogenetic Map3q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Sirpa
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3449
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.