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Gene: Ptprf (protein tyrosine phosphatase, receptor type, F) Rattus norvegicus
Symbol: Ptprf
Name: protein tyrosine phosphatase, receptor type, F
Description: Exhibits phosphate ion binding activity; signaling receptor binding activity; and transmembrane receptor protein tyrosine phosphatase activity. Involved in several processes, including homophilic cell adhesion via plasma membrane adhesion molecules; negative regulation of signal transduction; and regulation of cell projection organization. Localizes to several cellular components, including excitatory synapse; growth cone; and integral component of postsynaptic density membrane. Biomarker of obesity. Human ortholog(s) of this gene implicated in hyperinsulinism. Orthologous to human PTPRF (protein tyrosine phosphatase receptor type F); PARTICIPATES IN insulin signaling pathway; INTERACTS WITH (+)-schisandrin B; 1,3-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
Also known as: LAR; LARFN5C; leukocyte antigen-related (LAR) PTP receptor; leukocyte common antigen related; protein tyrosine phosphatase receptor-type F; receptor-type tyrosine-protein phosphatase F
Homo sapiens (human) : PTPRF (protein tyrosine phosphatase receptor type F)  HGNC  Alliance
Mus musculus (house mouse) : Ptprf (protein tyrosine phosphatase, receptor type, F)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ptprf (protein tyrosine phosphatase receptor type F)
Pan paniscus (bonobo/pygmy chimpanzee) : PTPRF (protein tyrosine phosphatase receptor type F)
Canis lupus familiaris (dog) : PTPRF (protein tyrosine phosphatase receptor type F)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ptprf (protein tyrosine phosphatase receptor type F)
Sus scrofa (pig) : PTPRF (protein tyrosine phosphatase receptor type F)
Chlorocebus sabaeus (African green monkey) : PTPRF (protein tyrosine phosphatase receptor type F)
Heterocephalus glaber (naked mole-rat) : Ptprf (protein tyrosine phosphatase receptor type F)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.05137,036,936 - 137,112,930 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5137,036,935 - 137,112,927 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05140,825,315 - 140,901,672 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45138,671,725 - 138,739,002 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15138,676,940 - 138,744,228 (-)NCBI
Celera5130,289,962 - 130,357,275 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Ptprf
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3453
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.