Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Ptprz1 (protein tyrosine phosphatase, receptor type Z1) Rattus norvegicus
Symbol: Ptprz1
Name: protein tyrosine phosphatase, receptor type Z1
Description: Exhibits fibroblast growth factor binding activity and protein tyrosine phosphatase activity. Involved in several processes, including hippocampus development; neurogenesis; and visual learning. Localizes to several cellular components, including integral component of postsynaptic density membrane; perineuronal net; and ruffle membrane. Biomarker of amyotrophic lateral sclerosis; middle cerebral artery infarction; status epilepticus; temporal lobe epilepsy; and visual epilepsy. Orthologous to human PTPRZ1 (protein tyrosine phosphatase receptor type Z1); INTERACTS WITH (+)-pilocarpine; (+)-schisandrin B; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 3F8 chondroitin sulfate proteoglycan; 3H1 keratan sulfate proteoglycan; 6B4 proteoglycan; phosphacan; Protein tyrosine phosphatase receptor-type zeta polypeptide; protein tyrosine phosphatase, receptor-type, Z polypeptide 1; Protein tyrosine phosphatase, receptor-type, zeta polypeptide; PTP zeta; Ptpz; PTPzeta-A; PTPzeta-B; PTPzeta-S; R-PTP-zeta; receptor-type tyrosine-protein phosphatase zeta; RPTPbeta
Homo sapiens (human) : PTPRZ1 (protein tyrosine phosphatase receptor type Z1)  HGNC  Alliance
Mus musculus (house mouse) : Ptprz1 (protein tyrosine phosphatase, receptor type Z, polypeptide 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ptprz1 (protein tyrosine phosphatase receptor type Z1)
Pan paniscus (bonobo/pygmy chimpanzee) : PTPRZ1 (protein tyrosine phosphatase receptor type Z1)
Canis lupus familiaris (dog) : PTPRZ1 (protein tyrosine phosphatase receptor type Z1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ptprz1 (protein tyrosine phosphatase receptor type Z1)
Sus scrofa (pig) : PTPRZ1 (protein tyrosine phosphatase receptor type Z1)
Chlorocebus sabaeus (African green monkey) : PTPRZ1 (protein tyrosine phosphatase receptor type Z1)
Heterocephalus glaber (naked mole-rat) : Ptprz1 (protein tyrosine phosphatase receptor type Z1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0449,941,046 - 50,140,764 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl449,941,304 - 50,140,762 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0449,730,302 - 49,927,328 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4449,267,521 - 49,468,692 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1449,498,094 - 49,699,266 (+)NCBI
Celera446,598,237 - 46,787,500 (+)NCBICelera
Cytogenetic Map4q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Ptprz1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3455
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.