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Gene: RT1-M3-1 (RT1 class Ib, locus M3, gene 1) Rattus norvegicus
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Symbol: RT1-M3-1
Name: RT1 class Ib, locus M3, gene 1
Description: Predicted to have peptide antigen binding activity and signaling receptor binding activity. Predicted to be involved in several processes, including antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; antigen processing and presentation of endogenous peptide antigen via MHC class Ib; and positive regulation of T cell mediated cytotoxicity. Predicted to localize to the external side of plasma membrane and extracellular space. Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; asthma (multiple); bone inflammation disease (multiple); eye disease (multiple); and inner ear disease (multiple). Orthologous to several human genes including HLA-A (major histocompatibility complex, class I, A); HLA-B (major histocompatibility complex, class I, B); and HLA-E (major histocompatibility complex, class I, E); PARTICIPATES IN allograft rejection pathway; antigen processing and presentation pathway; autoimmune thyroiditis pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,2',4,4'-Tetrabromodiphenyl ether; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 4B2/3.7; H2-M3; histocompatibility 2, M region locus 3; MHC class I antigen; MHC class I-b antigen M3; RanoM3; RanoM301; RanoM302; RT1 class Ib gene; RT1 class Ib gene, locus M3; RT1 class Ib, locus M3; RT1 class Ib, locus M3-1; RT1-M3
Orthologs:
No known orthologs. homologs ...
Related Pseudogenes: RT1-M3-2-ps   RT1-M3-3-ps  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0201,814,661 - 1,833,033 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0203,856,748 - 3,860,887 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4201,412,553 - 1,416,692 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1201,412,554 - 1,416,692 (-)NCBI
Celera202,034,641 - 2,038,780 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on RT1-M3-1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3494
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.