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Gene: Rasgrp1 (RAS guanyl releasing protein 1) Rattus norvegicus
Symbol: Rasgrp1
Name: RAS guanyl releasing protein 1
Description: Predicted to have several functions, including cation binding activity; diacylglycerol binding activity; and identical protein binding activity. Predicted to be involved in several processes, including positive regulation of cytokine production; positive regulation of lymphocyte differentiation; and regulation of intracellular signal transduction. Predicted to localize to Golgi apparatus; cytosol; and plasma membrane. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human RASGRP1 (RAS guanyl releasing protein 1); PARTICIPATES IN mitogen activated protein kinase signaling pathway; T cell receptor signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil.
Type: protein-coding
Also known as: calcium and DAG-regulated guanine nucleotide exchange factor II; CalDAG-GEF1; calDAG-GEFII; RAS guanyl releasing protein; RAS guanyl releasing protein 1 (calcium and DAG-regulated); RAS guanyl-releasing protein 1; Rasgrp
Homo sapiens (human) : RASGRP1 (RAS guanyl releasing protein 1)  HGNC  Alliance
Mus musculus (house mouse) : Rasgrp1 (RAS guanyl releasing protein 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rasgrp1 (RAS guanyl releasing protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : RASGRP1 (RAS guanyl releasing protein 1)
Canis lupus familiaris (dog) : RASGRP1 (RAS guanyl releasing protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rasgrp1 (RAS guanyl releasing protein 1)
Sus scrofa (pig) : RASGRP1 (RAS guanyl releasing protein 1)
Chlorocebus sabaeus (African green monkey) : RASGRP1 (RAS guanyl releasing protein 1)
Heterocephalus glaber (naked mole-rat) : Rasgrp1 (RAS guanyl releasing protein 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.03108,984,029 - 109,044,420 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3108,984,029 - 109,044,420 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03115,539,782 - 115,600,270 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43103,371,879 - 103,433,010 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13103,268,306 - 103,329,438 (-)NCBI
Celera3103,097,991 - 103,157,871 (-)NCBICelera
Cytogenetic Map3q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Rasgrp1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3539
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.