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Gene: Reg1a (regenerating family member 1 alpha) Rattus norvegicus
Symbol: Reg1a
Name: regenerating family member 1 alpha
Description: Exhibits growth factor activity; identical protein binding activity; and protein phosphatase binding activity. Involved in several processes, including animal organ regeneration; cellular response to gastrin; and positive regulation of epithelial cell proliferation. Localizes to several cellular components, including dendrite membrane; neuronal cell body membrane; and zymogen granule. Biomarker of colon cancer and myocardial infarction. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to several human genes including REG1A (regenerating family member 1 alpha); INTERACTS WITH acetylsalicylic acid; ammonium chloride; bisphenol A.
Type: protein-coding
Also known as: ICRF; islet cells regeneration factor; islet of Langerhans regenerating protein; LITHOST; lithostathine; pancreatic stone protein; pancreatic thread protein; PSP; PTP; rat regenerating islet-derived mouse homolog 1; RATLITHOST; RATRGPI; Reg; Reg1; regenerating islet-derived 1; regenerating islet-derived 1 alpha; regenerating islet-derived mouse homolog 1; regeneration protein lithostatin pancreatic stone protein; regeneration protein, lithostatin, pancreatic stone protein; Rgp1; RGPI
Homo sapiens (human) : REG1A (regenerating family member 1 alpha)  HGNC  Alliance
Mus musculus (house mouse) : Reg1 (regenerating islet-derived 1)  MGI  Alliance
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Reg1a (regenerating family member 1 alpha)
Heterocephalus glaber (naked mole-rat) : Reg1a (regenerating family member 1 alpha)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.04109,497,962 - 109,500,626 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4109,497,962 - 109,501,082 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04174,199,389 - 174,202,053 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44112,386,071 - 112,389,205 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14112,630,551 - 112,633,685 (+)NCBI
Celera499,924,400 - 99,927,064 (+)NCBICelera
Cytogenetic Map4q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Reg1a
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3552
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.