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Gene: Rgs4 (regulator of G-protein signaling 4) Rattus norvegicus
Symbol: Rgs4
Name: regulator of G-protein signaling 4
Description: Exhibits G-protein alpha-subunit binding activity and GTPase activator activity. Involved in several processes, including regulation of ion transport; regulation of signal transduction; and response to alkaloid. Localizes to several cellular components, including cytosol; nucleus; and plasma membrane. Used to study epilepsy. Biomarker of bladder disease; hypertension; lesion of sciatic nerve; opioid abuse; and status epilepticus. Orthologous to human RGS4 (regulator of G protein signaling 4); PARTICIPATES IN acetylcholine signaling pathway via muscarinic acetylcholine receptor; calcium signaling pathway via the calcium-sensing receptor; dopamine signaling pathway via D1 family of receptors; INTERACTS WITH (S)-amphetamine; 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine; 6-propyl-2-thiouracil.
Type: protein-coding
Also known as: RGP4
Homo sapiens (human) : RGS4 (regulator of G protein signaling 4)  HGNC  Alliance
Mus musculus (house mouse) : Rgs4 (regulator of G-protein signaling 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rgs4 (regulator of G protein signaling 4)
Pan paniscus (bonobo/pygmy chimpanzee) : RGS4 (regulator of G protein signaling 4)
Canis lupus familiaris (dog) : RGS4 (regulator of G protein signaling 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rgs4 (regulator of G protein signaling 4)
Sus scrofa (pig) : RGS4 (regulator of G protein signaling 4)
Chlorocebus sabaeus (African green monkey) : RGS4 (regulator of G protein signaling 4)
Heterocephalus glaber (naked mole-rat) : Rgs4 (regulator of G protein signaling 4)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01388,054,817 - 88,061,108 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1388,054,817 - 88,061,108 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01392,682,956 - 92,689,247 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41385,533,882 - 85,540,173 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11385,548,069 - 85,554,361 (-)NCBI
Celera1381,602,391 - 81,608,682 (-)NCBICelera
Cytogenetic Map13q24NCBI
RH 3.4 Map13510.9RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Rgs4
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3567
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.