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Gene: Ncor1 (nuclear receptor co-repressor 1) Rattus norvegicus
Symbol: Ncor1
Name: nuclear receptor co-repressor 1
Description: Exhibits several functions, including RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; nuclear receptor binding activity; and peroxisome proliferator activated receptor binding activity. Involved in animal organ development; negative regulation of transcription, DNA-templated; and positive regulation of cell population proliferation. Localizes to nucleus and perinuclear region of cytoplasm. Predicted to colocalize with Sin3 complex. Used to study anxiety disorder and polycystic ovary syndrome. Biomarker of hypothyroidism and polycystic ovary syndrome. Orthologous to human NCOR1 (nuclear receptor corepressor 1); PARTICIPATES IN aldosterone signaling pathway; androgen signaling pathway; cortisol signaling pathway; INTERACTS WITH 17beta-estradiol; 2,4-dinitrotoluene; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: MGC116328; N-CoR; N-Cor/SMRT corepressor Rip13; N-Cor/SMRT corepressor, Rip13; N-CoR1; NCoR; nuclear receptor corepressor 1; Rxrip13
Homo sapiens (human) : NCOR1 (nuclear receptor corepressor 1)  HGNC  Alliance
Mus musculus (house mouse) : Ncor1 (nuclear receptor co-repressor 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ncor1 (nuclear receptor corepressor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NCOR1 (nuclear receptor corepressor 1)
Canis lupus familiaris (dog) : NCOR1 (nuclear receptor corepressor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ncor1 (nuclear receptor corepressor 1)
Sus scrofa (pig) : NCOR1 (nuclear receptor corepressor 1)
Chlorocebus sabaeus (African green monkey) : NCOR1 (nuclear receptor corepressor 1)
Heterocephalus glaber (naked mole-rat) : Ncor1 (nuclear receptor corepressor 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01048,629,121 - 48,772,890 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1048,629,121 - 48,772,890 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01048,417,490 - 48,559,309 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41048,481,110 - 48,628,538 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11048,495,233 - 48,511,932 (-)NCBI
Celera1046,245,514 - 46,388,593 (-)NCBICelera
Cytogenetic Map10q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Ncor1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3612
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.