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Gene: Scn10a (sodium voltage-gated channel alpha subunit 10) Rattus norvegicus
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Symbol: Scn10a
Name: sodium voltage-gated channel alpha subunit 10
Description: Exhibits voltage-gated sodium channel activity. Involved in odontogenesis of dentin-containing tooth; sensory perception of pain; and sodium ion transport. Localizes to several cellular components, including clathrin complex; glutamatergic synapse; and integral component of presynaptic membrane. Used to study sciatic neuropathy. Human ortholog(s) of this gene implicated in familial episodic pain syndrome 2. Orthologous to human SCN10A (sodium voltage-gated channel alpha subunit 10); PARTICIPATES IN alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacodynamics pathway; INTERACTS WITH (+)-trans-(S)-allethrin; allethrin; atrazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Na(V)1.8; Nav1.8; peripheral nerve sodium channel 3; PN3; sensory neuron sodium channel; sodium channel protein type 10 subunit alpha; sodium channel protein type X subunit alpha; sodium channel type X alpha polypeptide; sodium channel voltage-gated type X alpha polypeptide; sodium channel, voltage-gated, type 10, alpha polypeptide; sodium channel, voltage-gated, type X, alpha; sodium channel, voltage-gated, type X, alpha polypeptide; sodium channel, voltage-gated, type X, alpha subunit; voltage-gated sodium channel subunit alpha Nav1.8
Orthologs:
Homo sapiens (human) : SCN10A (sodium voltage-gated channel alpha subunit 10)  HGNC  Alliance
Mus musculus (house mouse) : Scn10a (sodium channel, voltage-gated, type X, alpha)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Scn10a (sodium voltage-gated channel alpha subunit 10)
Pan paniscus (bonobo/pygmy chimpanzee) : SCN10A (sodium voltage-gated channel alpha subunit 10)
Canis lupus familiaris (dog) : SCN10A (sodium voltage-gated channel alpha subunit 10)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Scn10a (sodium voltage-gated channel alpha subunit 10)
Sus scrofa (pig) : SCN10A (sodium voltage-gated channel alpha subunit 10)
Chlorocebus sabaeus (African green monkey) : SCN10A (sodium voltage-gated channel alpha subunit 10)
Heterocephalus glaber (naked mole-rat) : Scn10a (sodium voltage-gated channel alpha subunit 10)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08128,298,593 - 128,416,896 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8128,298,594 - 128,416,650 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08127,503,061 - 127,620,197 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48124,578,222 - 124,690,458 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18124,597,959 - 124,710,195 (-)NCBI
Celera8118,500,856 - 118,611,564 (-)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Scn10a
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3629
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-03-04
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.