Gene: Scn8a (sodium voltage-gated channel alpha subunit 8) Rattus norvegicus
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Symbol: Scn8a
Name: sodium voltage-gated channel alpha subunit 8
Description: Exhibits sodium ion binding activity and voltage-gated sodium channel activity; involved in nervous system development, neuronal action potential, and sodium ion transport; localizes to several cellular components, including the axon, glutamatergic synapse, and intrinsic component of plasma membrane; biomarker of congestive heart failure; orthologous to human SCN8A (sodium voltage-gated channel alpha subunit 8); INTERACTS WITH (+)-pilocarpine; (+)-trans-(S)-allethrin; 4,5,6,7-TETRABROMOBENZOTRIAZOLE.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Na+ channel; naCh6; peripheral nerve protein type 4; PN4; sodium channel 6; sodium channel protein type 8 subunit alpha; sodium channel protein type VIII subunit alpha; sodium channel voltage-gated type VIII alpha polypeptide; sodium channel, voltage gated, type VIII, alpha subunit; sodium channel, voltage-gated, type 8, alpha polypeptide; sodium channel, voltage-gated, type 8, alpha subunit; sodium channel, voltage-gated, type VIII, alpha; sodium channel, voltage-gated, type VIII, alpha polypeptide; voltage-gated sodium channel subunit alpha Nav1.6
Orthologs:
Homo sapiens (human) : SCN8A (sodium voltage-gated channel alpha subunit 8)  HGNC  Alliance
Mus musculus (house mouse) : Scn8a (sodium channel, voltage-gated, type VIII, alpha)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Scn8a (sodium voltage-gated channel alpha subunit 8)
Pan paniscus (bonobo/pygmy chimpanzee) : SCN8A (sodium voltage-gated channel alpha subunit 8)
Canis lupus familiaris (dog) : SCN8A (sodium voltage-gated channel alpha subunit 8)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Scn8a (sodium voltage-gated channel alpha subunit 8)
Sus scrofa (pig) : SCN8A (sodium voltage-gated channel alpha subunit 8)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.07142,575,629 - 142,683,659 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.07140,377,038 - 140,485,139 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47139,686,180 - 139,794,282 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17139,762,616 - 139,870,727 (+)NCBI
Celera7128,450,559 - 128,618,862 (+)NCBICelera
Cytogenetic Map7q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Scn8a
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3638
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.