Gene: Scnn1a (sodium channel epithelial 1 alpha subunit) Rattus norvegicus
Analyze
Symbol: Scnn1a
Name: sodium channel epithelial 1 alpha subunit
Description: Exhibits WW domain binding activity, actin binding activity, and ligand-gated sodium channel activity; predicted to contribute to sodium channel activity; involved in regulation of body fluid levels and sodium ion transport; localizes to the apical plasma membrane, cytoplasm, and sperm principal piece; used to study nephrotic syndrome; orthologous to human SCNN1A (sodium channel epithelial 1 alpha subunit); PARTICIPATES IN amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; bumetanide pharmacodynamics pathway; INTERACTS WITH 2,4,6-trinitrotoluene; 2,4-dinitrotoluene; 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: alpha-ENaC; alpha-NaCH; amiloride-sensitive epithelial sodium channel alpha subunit; amiloride-sensitive sodium channel subunit alpha; ENaCA; epithelial Na(+) channel subunit alpha; epithelial sodium channel alpha subunit; nonvoltage-gated sodium channel 1 subunit alpha; SCNEA; Sodium channel nonvoltage-gated 1 alpha (epithelial); sodium channel, non-voltage-gated 1 alpha subunit; sodium channel, nonvoltage-gated 1 alpha; sodium channel, nonvoltage-gated, type 1, alpha subunit; sodium channel, nonvoltage-gated, type I, alpha; sodium channel, nonvoltage-gated, type I, alpha polypeptide
Orthologs:
Homo sapiens (human) : SCNN1A (sodium channel epithelial 1 alpha subunit)  HGNC  Alliance
Mus musculus (house mouse) : Scnn1a (sodium channel, nonvoltage-gated 1 alpha)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Scnn1a (sodium channel epithelial 1 alpha subunit)
Pan paniscus (bonobo/pygmy chimpanzee) : SCNN1A (sodium channel epithelial 1 alpha subunit)
Canis lupus familiaris (dog) : SCNN1A (sodium channel epithelial 1 alpha subunit)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Scnn1a (sodium channel epithelial 1 alpha subunit)
Sus scrofa (pig) : SCNN1A (sodium channel epithelial 1 alpha subunit)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.04157,834,339 - 157,860,472 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04224,853,710 - 224,877,459 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44161,445,936 - 161,469,267 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14161,690,871 - 161,714,200 (+)NCBI
Celera4146,859,208 - 146,882,414 (+)NCBICelera
Cytogenetic Map4q42NCBI
RH 3.4 Map41000.7RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Scnn1a
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3639
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-05-07
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.