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Gene: Scnn1g (sodium channel epithelial 1 subunit gamma) Rattus norvegicus
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Symbol: Scnn1g
Name: sodium channel epithelial 1 subunit gamma
CRRD ID: 3641
Description: Exhibits WW domain binding activity and ligand-gated sodium channel activity. Predicted to contribute to sodium channel activity. Involved in response to hypoxia; sodium ion transport; and wound healing, spreading of epidermal cells. Localizes to apical plasma membrane and cell surface. Human ortholog(s) of this gene implicated in Liddle syndrome; autosomal recessive pseudohypoaldosteronism type 1; bronchiectasis 3; and pseudohypoaldosteronism. Orthologous to human SCNN1G (sodium channel epithelial 1 subunit gamma); PARTICIPATES IN amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; bumetanide pharmacodynamics pathway; INTERACTS WITH 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine; 3-isobutyl-1-methyl-7H-xanthine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: amiloride sensitive sodium channel gamma1 subunit; amiloride-sensitive sodium channel subunit gamma; ENaC; epithelial Na(+) channel subunit gamma; epithelial sodium channel gamma subunit; gamma-ENaC; gamma-NaCH; nonvoltage-gated sodium channel 1 subunit gamma; SCNEG; sodium channel epithelial 1 gamma subunit; Sodium channel nonvoltage-gated 1 gamma (epithelial); sodium channel, non-voltage-gated 1, gamma subunit; sodium channel, nonvoltage-gated 1 gamma; sodium channel, nonvoltage-gated 1, gamma; Sodium channel, nonvoltage-gated 1, gamma (epithelial); sodium channel, nonvoltage-gated, type I, gamma
Orthologs:
Homo sapiens (human) : SCNN1G (sodium channel epithelial 1 subunit gamma)  HGNC  Alliance
Mus musculus (house mouse) : Scnn1g (sodium channel, nonvoltage-gated 1 gamma)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Scnn1g (sodium channel epithelial 1 gamma subunit)
Pan paniscus (bonobo/pygmy chimpanzee) : SCNN1G (sodium channel epithelial 1 subunit gamma)
Canis lupus familiaris (dog) : SCNN1G (sodium channel epithelial 1 subunit gamma)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Scnn1g (sodium channel epithelial 1 subunit gamma)
Sus scrofa (pig) : SCNN1G (sodium channel epithelial 1 subunit gamma)
Chlorocebus sabaeus (African green monkey) : SCNN1G (sodium channel epithelial 1 subunit gamma)
Heterocephalus glaber (naked mole-rat) : Scnn1g (sodium channel epithelial 1 subunit gamma)
more info ...
Is Marker For: Strains:   SHR.BN-(D1Mit3-Igf2)/Ipcv  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01191,704,397 - 191,738,271 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1191,704,311 - 191,738,268 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01198,620,974 - 198,655,013 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41180,555,660 - 180,589,534 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11180,695,574 - 180,729,447 (+)NCBI
Celera1174,023,130 - 174,057,000 (+)NCBICelera
Cytogenetic Map1q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

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Nomenclature History
RGD Curation Notes
 
More on Scnn1g
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3641
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.