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Gene: Slc12a3 (solute carrier family 12 member 3) Rattus norvegicus
Symbol: Slc12a3
Name: solute carrier family 12 member 3
CRRD ID: 3686
Description: Exhibits enzyme binding activity and sodium:chloride symporter activity. Involved in chloride transport and sodium ion transmembrane transport. Localizes to apical plasma membrane and vesicle. Human ortholog(s) of this gene implicated in Gitelman syndrome and essential hypertension. Orthologous to human SLC12A3 (solute carrier family 12 member 3); PARTICIPATES IN amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; bumetanide pharmacodynamics pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: na-Cl symporter; NCC; solute carrier family 12 (sodium/chloride transporter), member 3; solute carrier family 12 (sodium/chloride transporters), member 3; solute carrier family 12, member 3; thiazide-sensitive Na-Cl cotransporter; thiazide-sensitive sodium-chloride cotransporter; TSC
Homo sapiens (human) : SLC12A3 (solute carrier family 12 member 3)  HGNC  Alliance
Mus musculus (house mouse) : Slc12a3 (solute carrier family 12, member 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Slc12a3 (solute carrier family 12 member 3)
Pan paniscus (bonobo/pygmy chimpanzee) : SLC12A3 (solute carrier family 12 member 3)
Canis lupus familiaris (dog) : SLC12A3 (solute carrier family 12 member 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Slc12a3 (solute carrier family 12 member 3)
Sus scrofa (pig) : SLC12A3 (solute carrier family 12 member 3)
Chlorocebus sabaeus (African green monkey) : SLC12A3 (solute carrier family 12 member 3)
Heterocephalus glaber (naked mole-rat) : Slc12a3 (solute carrier family 12 member 3)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01911,106,033 - 11,144,674 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1911,106,033 - 11,144,641 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01911,084,193 - 11,122,657 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41911,070,329 - 11,109,634 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11911,075,156 - 11,114,460 (-)NCBI
Celera1910,518,752 - 10,557,092 (-)NCBICelera
Cytogenetic Map19p13-p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Slc12a3
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3686
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.