Gene: Slc18a2 (solute carrier family 18 member A2) Rattus norvegicus
Symbol: Slc18a2
Name: solute carrier family 18 member A2
Description: Exhibits several functions, including drug binding activity, enzyme binding activity, and transmembrane transporter activity; involved in several processes, including aging, aminergic neurotransmitter loading into synaptic vesicle, and cellular response to ammonium ion; localizes to several cellular components, including the cytoplasm, dopaminergic synapse, and neuronal cell body; used to study Parkinson's disease and type 1 diabetes mellitus; biomarker of Machado-Joseph disease, Parkinson's disease, substance-related disorder, and toxic encephalopathy; orthologous to human SLC18A2 (solute carrier family 18 member A2); PARTICIPATES IN dopamine biosynthetic pathway; epinephrine biosynthetic pathway; norepinephrine biosynthetic pathway; INTERACTS WITH (R)-noradrenaline; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 17alpha-ethynylestradiol.
Type: protein-coding
Also known as: MNAT; monoamine transporter; solute carrier family 18 (vesicular monoamine transporter), member 2; solute carrier family 18 (vesicular monoamine), member 2; Solute carrier family 18 A2 (vesicular monoamine transporter 2); solute carrier family 18 member 2; solute carrier family 18, member 2; synaptic vesicular amine transporter; VAT2; vesicular amine transporter 2; VMAT-2; VMAT2
Homo sapiens (human) : SLC18A2 (solute carrier family 18 member A2)  HGNC  Alliance
Mus musculus (house mouse) : Slc18a2 (solute carrier family 18 (vesicular monoamine), member 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Slc18a2 (solute carrier family 18 member A2)
Pan paniscus (bonobo/pygmy chimpanzee) : SLC18A2 (solute carrier family 18 member A2)
Canis lupus familiaris (dog) : SLC18A2 (solute carrier family 18 member A2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Slc18a2 (solute carrier family 18 member A2)
Sus scrofa (pig) : SLC18A2 (solute carrier family 18 member A2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01280,397,831 - 280,457,968 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01287,782,713 - 287,818,452 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41265,789,917 - 265,824,551 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11266,000,961 - 266,035,596 (+)NCBI
Celera1254,067,617 - 254,102,150 (+)NCBICelera
Cytogenetic Map1q55NCBI
RH 3.4 Map11709.1RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Slc18a2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3694
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.