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Gene: Slc18a2 (solute carrier family 18 member A2) Rattus norvegicus
Symbol: Slc18a2
Name: solute carrier family 18 member A2
Description: Exhibits several functions, including enzyme binding activity; heat shock protein binding activity; and transmembrane transporter activity. Involved in several processes, including aminergic neurotransmitter loading into synaptic vesicle; insulin secretion; and response to corticosterone. Localizes to several cellular components, including cytoplasmic vesicle membrane; dopaminergic synapse; and neuronal cell body. Used to study Parkinson's disease and type 1 diabetes mellitus. Biomarker of Machado-Joseph disease; Parkinson's disease; substance-related disorder; and toxic encephalopathy. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human SLC18A2 (solute carrier family 18 member A2); PARTICIPATES IN dopamine biosynthetic pathway; epinephrine biosynthetic pathway; norepinephrine biosynthetic pathway; INTERACTS WITH (R)-noradrenaline; 17alpha-ethynylestradiol; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
Also known as: MNAT; monoamine transporter; solute carrier family 18 (vesicular monoamine transporter), member 2; solute carrier family 18 (vesicular monoamine), member 2; Solute carrier family 18 A2 (vesicular monoamine transporter 2); solute carrier family 18 member 2; solute carrier family 18, member 2; synaptic vesicular amine transporter; VAT2; vesicular amine transporter 2; VMAT-2; VMAT2
Homo sapiens (human) : SLC18A2 (solute carrier family 18 member A2)  HGNC  Alliance
Mus musculus (house mouse) : Slc18a2 (solute carrier family 18 (vesicular monoamine), member 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Slc18a2 (solute carrier family 18 member A2)
Pan paniscus (bonobo/pygmy chimpanzee) : SLC18A2 (solute carrier family 18 member A2)
Canis lupus familiaris (dog) : SLC18A2 (solute carrier family 18 member A2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Slc18a2 (solute carrier family 18 member A2)
Sus scrofa (pig) : SLC18A2 (solute carrier family 18 member A2)
Chlorocebus sabaeus (African green monkey) : SLC18A2 (solute carrier family 18 member A2)
Heterocephalus glaber (naked mole-rat) : Slc18a2 (solute carrier family 18 member A2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01280,397,831 - 280,457,968 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1280,423,079 - 280,457,148 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01287,782,713 - 287,818,452 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41265,789,917 - 265,824,551 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11266,000,961 - 266,035,596 (+)NCBI
Celera1254,067,617 - 254,102,150 (+)NCBICelera
Cytogenetic Map1q55NCBI
RH 3.4 Map11709.1RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Slc18a2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3694
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.