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Gene: Slc1a3 (solute carrier family 1 member 3) Rattus norvegicus
Symbol: Slc1a3
Name: solute carrier family 1 member 3
Description: Exhibits high-affinity glutamate transmembrane transporter activity. Involved in malate-aspartate shuttle; neurotransmitter uptake; and response to inorganic substance. Localizes to several cellular components, including basal plasma membrane; dendritic spine; and neuronal cell body. Human ortholog(s) of this gene implicated in episodic ataxia type 6. Orthologous to human SLC1A3 (solute carrier family 1 member 3); PARTICIPATES IN nicotinamide adenine dinucleotide metabolic pathway; glutamate signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: EAAT1; excitatory amino acid transporter 1; GLAST; GLAST-1; glial glutamate transporter; GluT-1; glutamate transporter; glutamate/aspartate transporter; sodium-dependent glutamate/aspartate transporter 1; solute carrier family 1 (glial high affinity glutamate transporter), member 3; solute carrier family 1, member 3
Homo sapiens (human) : SLC1A3 (solute carrier family 1 member 3)  HGNC  Alliance
Mus musculus (house mouse) : Slc1a3 (solute carrier family 1 (glial high affinity glutamate transporter), member 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Slc1a3 (solute carrier family 1 member 3)
Pan paniscus (bonobo/pygmy chimpanzee) : SLC1A3 (solute carrier family 1 member 3)
Canis lupus familiaris (dog) : SLC1A3 (solute carrier family 1 member 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Slc1a3 (solute carrier family 1 member 3)
Sus scrofa (pig) : SLC1A3 (solute carrier family 1 member 3)
Chlorocebus sabaeus (African green monkey) : SLC1A3 (solute carrier family 1 member 3)
Heterocephalus glaber (naked mole-rat) : Slc1a3 (solute carrier family 1 member 3)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0257,860,881 - 57,935,363 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl257,860,834 - 57,935,363 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0279,348,443 - 79,422,645 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4258,270,236 - 58,347,613 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1258,198,470 - 58,275,846 (-)NCBI
Celera253,367,866 - 53,442,429 (-)NCBICelera
Cytogenetic Map2q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Slc1a3
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3698
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.