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Gene: Slc6a4 (solute carrier family 6 member 4) Rattus norvegicus
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Symbol: Slc6a4
Name: solute carrier family 6 member 4
Description: Exhibits several functions, including cocaine binding activity; cytoskeletal protein binding activity; and protein homodimerization activity. Involved in several processes, including cellular response to cGMP; cellular response to retinoic acid; and negative regulation of nervous system development. Localizes to several cellular components, including the integral component of synaptic membrane; membrane raft; and serotonergic synapse. Used to study anxiety disorder; mental depression; and pulmonary hypertension. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; anxiety disorder (multiple); autistic disorder; dyspepsia; and heart disease (multiple). Orthologous to human SLC6A4 (solute carrier family 6 member 4); PARTICIPATES IN alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacodynamics pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; (S)-amphetamine; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 5HT transporter; 5HTT; serotonin transporter; SERT; sodium-dependent serotonin transporter; solute carrier family 6 (neurotransmitter transporter serotonin) member 4; solute carrier family 6 (neurotransmitter transporter serotonin) member 4 (5-hydroxytryptamine (serotonin) transporter); solute carrier family 6 (neurotransmitter transporter serotonin) member 4 (5-hydroxytryptamine (serotonin) transporter); solute carrier family 6 (neurotransmitter transporter), member 4; solute carrier family 6 (neurotransmitter transporter, serotonin), member 4; solute carrier family 6, member 4
Orthologs:
Homo sapiens (human) : SLC6A4 (solute carrier family 6 member 4)  HGNC  Alliance
Mus musculus (house mouse) : Slc6a4 (solute carrier family 6 (neurotransmitter transporter, serotonin), member 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Slc6a4 (solute carrier family 6 member 4)
Pan paniscus (bonobo/pygmy chimpanzee) : SLC6A4 (solute carrier family 6 member 4)
Canis lupus familiaris (dog) : SLC6A4 (solute carrier family 6 member 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Slc6a4 (solute carrier family 6 member 4)
Sus scrofa (pig) : SLC6A4 (solute carrier family 6 member 4)
more info ...
Allele / Splice: Slc6a4m1Hubr  
Genetic Models: WI-Slc6a4m1Hubr+/- WI-Slc6a4m1Hubr-/-
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01063,153,656 - 63,188,377 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01062,851,326 - 62,872,481 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41067,134,790 - 67,155,891 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11067,148,412 - 67,197,988 (-)NCBI
Celera1060,845,942 - 60,866,725 (+)NCBICelera
Cytogenetic Map10q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Slc6a4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3714
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.