Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Slc6a3 (solute carrier family 6 member 3) Rattus norvegicus
Symbol: Slc6a3
Name: solute carrier family 6 member 3
CRRD ID: 3715
Description: Exhibits several functions, including dopamine:sodium symporter activity; drug binding activity; and enzyme binding activity. Involved in several processes, including dopamine transport; response to cAMP; and response to ethanol. Localizes to neuron projection and plasma membrane. Biomarker of heroin dependence; hyperprolactinemia; hypertension; and malignant glioma. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder; nicotine dependence; and obesity. Orthologous to human SLC6A3 (solute carrier family 6 member 3); PARTICIPATES IN alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacodynamics pathway; INTERACTS WITH (S)-amphetamine; (S)-nicotine; 1-[2-(benzhydryloxy)ethyl]-4-(3-phenylpropyl)piperazine.
Type: protein-coding
Also known as: DA transporter; DAT; Dat1; sodium-dependent dopamine transporter; Solute carrier family 6 (neurotransmitter transporter dopamine) member 3; solute carrier family 6 (neurotransmitter transporter), member 3; Solute carrier family 6 (neurotransmitter transporter, dopamine), member 3; solute carrier family 6, member 3
Homo sapiens (human) : SLC6A3 (solute carrier family 6 member 3)  HGNC  Alliance
Mus musculus (house mouse) : Slc6a3 (solute carrier family 6 (neurotransmitter transporter, dopamine), member 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Slc6a3 (solute carrier family 6 member 3)
Pan paniscus (bonobo/pygmy chimpanzee) : SLC6A3 (solute carrier family 6 member 3)
Canis lupus familiaris (dog) : SLC6A3 (solute carrier family 6 member 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Slc6a3 (solute carrier family 6 member 3)
Sus scrofa (pig) : SLC6A3 (solute carrier family 6 member 3)
Chlorocebus sabaeus (African green monkey) : SLC6A3 (solute carrier family 6 member 3)
Heterocephalus glaber (naked mole-rat) : Slc6a3 (solute carrier family 6 member 3)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0132,323,011 - 32,363,983 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl132,321,580 - 32,363,983 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0133,745,060 - 33,788,878 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4130,516,568 - 30,557,540 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1130,518,078 - 30,558,861 (-)NCBI
Celera128,357,426 - 28,397,883 (-)NCBICelera
Cytogenetic Map1p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Slc6a3
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3715
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.