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Gene: Slc6a3 (solute carrier family 6 member 3) Rattus norvegicus
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Symbol: Slc6a3
Name: solute carrier family 6 member 3
Description: Exhibits several functions, including dopamine:sodium symporter activity; drug binding activity; and enzyme binding activity. Involved in several processes, including aging; response to cAMP; and response to ethanol. Localizes to the dopaminergic synapse; integral component of synaptic membrane; and neuron projection. Biomarker of heroin dependence; hyperprolactinemia; hypertension; and malignant glioma. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder; nicotine dependence; and obesity. Orthologous to human SLC6A3 (solute carrier family 6 member 3); PARTICIPATES IN alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacodynamics pathway; INTERACTS WITH (RS)-amphetamine; (S)-amphetamine; (S)-nicotine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: DA transporter; DAT; Dat1; sodium-dependent dopamine transporter; Solute carrier family 6 (neurotransmitter transporter dopamine) member 3; solute carrier family 6 (neurotransmitter transporter), member 3; Solute carrier family 6 (neurotransmitter transporter, dopamine), member 3; solute carrier family 6, member 3
Orthologs:
Homo sapiens (human) : SLC6A3 (solute carrier family 6 member 3)  HGNC  Alliance
Mus musculus (house mouse) : Slc6a3 (solute carrier family 6 (neurotransmitter transporter, dopamine), member 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Slc6a3 (solute carrier family 6 member 3)
Pan paniscus (bonobo/pygmy chimpanzee) : SLC6A3 (solute carrier family 6 member 3)
Canis lupus familiaris (dog) : SLC6A3 (solute carrier family 6 member 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Slc6a3 (solute carrier family 6 member 3)
Sus scrofa (pig) : SLC6A3 (solute carrier family 6 member 3)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0132,323,011 - 32,363,983 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0133,745,060 - 33,788,878 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4130,516,568 - 30,557,540 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1130,518,078 - 30,558,861 (-)NCBI
Celera128,357,426 - 28,397,883 (-)NCBICelera
Cytogenetic Map1p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Slc6a3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3715
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.