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Gene: Slc9a3 (solute carrier family 9 member A3) Rattus norvegicus
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Symbol: Slc9a3
Name: solute carrier family 9 member A3
Description: Exhibits sodium:proton antiporter activity. Involved in several processes, including receptor-mediated endocytosis; regulation of pH; and response to glucocorticoid. Localizes to the apical plasma membrane and brush border membrane. Used to study hypertension. Biomarker of obesity and renovascular hypertension. Human ortholog(s) of this gene implicated in congenital secretory sodium diarrhea 8. Orthologous to human SLC9A3 (solute carrier family 9 member A3); PARTICIPATES IN endothelin signaling pathway; bile acid transport pathway; INTERACTS WITH 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine; acrylamide; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: na(+)/H(+) exchanger 3; NHE-3; Nhe3; plasma membrane ion transport protein; sodium/hydrogen exchanger 3; Solute carrier family 9 (sodium/hydrogen exchanger 3) antiporter 3 Na+/H+ (amiloride insensitive); Solute carrier family 9 (sodium/hydrogen exchanger 3), antiporter 3, Na+/H+ (amiloride insensitive); solute carrier family 9 (sodium/hydrogen exchanger), member 3; solute carrier family 9 member 3; solute carrier family 9, member 3; solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
Orthologs:
Homo sapiens (human) : SLC9A3 (solute carrier family 9 member A3)  HGNC  Alliance
Mus musculus (house mouse) : Slc9a3 (solute carrier family 9 (sodium/hydrogen exchanger), member 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Slc9a3 (solute carrier family 9 member A3)
Pan paniscus (bonobo/pygmy chimpanzee) : SLC9A3 (solute carrier family 9 member A3)
Canis lupus familiaris (dog) : SLC9A3 (solute carrier family 9 member A3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Slc9a3 (solute carrier family 9 member A3)
Sus scrofa (pig) : SLC9A3 (solute carrier family 9 member A3)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0131,731,652 - 31,777,144 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0133,159,607 - 33,201,753 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4129,930,908 - 29,973,686 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1129,933,852 - 29,976,631 (-)NCBI
Celera127,776,582 - 27,819,219 (-)NCBICelera
Cytogenetic Map1p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Slc9a3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3720
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.