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Gene: Sparc (secreted protein acidic and cysteine rich) Rattus norvegicus
Symbol: Sparc
Name: secreted protein acidic and cysteine rich
Description: Exhibits calcium ion binding activity. Involved in several processes, including animal organ development; response to L-ascorbic acid; and response to lead ion. Localizes to several cellular components, including extracellular space; glutamatergic synapse; and vesicle. Biomarker of diabetic angiopathy; membranoproliferative glomerulonephritis; membranous glomerulonephritis; myocardial infarction; and stomach carcinoma. Human ortholog(s) of this gene implicated in cervix carcinoma; endometrial carcinoma; and osteogenesis imperfecta type 17. Orthologous to human SPARC (secreted protein acidic and cysteine rich); INTERACTS WITH 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
Also known as: basement-membrane protein 40; BM-40; ON; osteonectin; Secreted acidic cystein-rich glycoprotein (osteonectin); secreted acidic cysteine rich glycoprotein; secreted protein acidic and rich in cysteine; secreted protein, acidic, cysteine-rich (osteonectin)
Homo sapiens (human) : SPARC (secreted protein acidic and cysteine rich)  HGNC  Alliance
Mus musculus (house mouse) : Sparc (secreted acidic cysteine rich glycoprotein)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sparc (secreted protein acidic and cysteine rich)
Pan paniscus (bonobo/pygmy chimpanzee) : SPARC (secreted protein acidic and cysteine rich)
Canis lupus familiaris (dog) : SPARC (secreted protein acidic and cysteine rich)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sparc (secreted protein acidic and cysteine rich)
Sus scrofa (pig) : SPARC (secreted protein acidic and cysteine rich)
Chlorocebus sabaeus (African green monkey) : SPARC (secreted protein acidic and cysteine rich)
Heterocephalus glaber (naked mole-rat) : Sparc (secreted protein acidic and cysteine rich)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01040,742,390 - 40,764,232 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1040,742,400 - 40,764,185 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01040,573,510 - 40,595,261 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41040,809,730 - 40,831,481 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11040,823,352 - 40,845,104 (-)NCBI
Celera1038,848,158 - 38,869,906 (-)NCBICelera
Cytogenetic Map10q22NCBI
RH 3.4 Map10414.6RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Sparc
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3742
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.