Gene: Serpine2 (serpin family E member 2) Rattus norvegicus
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Symbol: Serpine2
Name: serpin family E member 2
Description: Exhibits heparin binding activity and serine-type endopeptidase inhibitor activity; involved in several processes, including dense core granule biogenesis, embryo implantation, and negative regulation of blood coagulation; localizes to the extracellular space, membrane, and neuronal cell body; biomarker of brain edema and hypertension; orthologous to human SERPINE2 (serpin family E member 2); PARTICIPATES IN fibrinolysis pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Clozapine Regulated Gene; CRG; GDN; Gdnpn1; glia-derived nexin; glia-derived nexin / preotease nexin I; Glia-derived nexin/protease nexin I; peptidase inhibitor 7; PI-7; plasminogen activator inhibitor type 1; Pn-1; protease nexin 1; protease nexin I; protease nexin PN-1; serine (or cysteine) peptidase inhibitor, clade E, member 2; serine (or cysteine) proteinase inhibitor clade E (nexin plasminogen activator inhibitor type 1) member 2; serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1) , member 2; serine (or cysteine) proteinase inhibitor, clade E, member 2; serine protease inhibitor 4; serpin E2; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2; serpin peptidase inhibitor, clade E, member 2; Spin4
Orthologs:
Homo sapiens (human) : SERPINE2 (serpin family E member 2)  HGNC  Alliance
Mus musculus (house mouse) : Serpine2 (serine (or cysteine) peptidase inhibitor, clade E, member 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Serpine2 (serpin family E member 2)
Pan paniscus (bonobo/pygmy chimpanzee) : SERPINE2 (serpin family E member 2)
Canis lupus familiaris (dog) : SERPINE2 (serpin family E member 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Serpine2 (serpin family E member 2)
Sus scrofa (pig) : SERPINE2 (serpin family E member 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0985,560,852 - 85,629,410 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0985,312,140 - 85,375,577 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4979,091,414 - 79,166,330 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1979,275,580 - 79,302,222 (-)NCBI
Celera978,614,628 - 78,678,321 (-)NCBICelera
Cytogenetic Map9q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Serpine2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3748
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.