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Gene: Spink1 (serine peptidase inhibitor, Kazal type 1) Rattus norvegicus
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Symbol: Spink1
Name: serine peptidase inhibitor, Kazal type 1
Description: Exhibits serine-type endopeptidase inhibitor activity. Involved in several processes, including negative regulation of serine-type endopeptidase activity; positive regulation of secretion; and response to ethanol. Localizes to the cytoplasm and extracellular space. Human ortholog(s) of this gene implicated in pancreatitis. Orthologous to human SPINK1 (serine peptidase inhibitor, Kazal type 1); INTERACTS WITH 1,1-dichloroethene; 1,2-dimethylhydrazine; 1-nitropropane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cholecystokinin-releasing peptide; monitor peptide; pancreatic cholecystokinin(CCK) releasing peptide; pancreatic secretory trypsin inhibitor; pancreatic secretory trypsin inhibitor I; pancreatic secretory trypsin inhibitor-61; Psti-1; PSTI-61; PSTI-I; serine peptidase inhibitor, Kazal type 3; Serine protease inhibitor kanzal type 1/ Trypsin inhibitor-like protein pancreatic; serine protease inhibitor Kazal-type 1; Serine protease inhibitor, kanzal type 1/ Trypsin inhibitor-like protein, pancreatic; serine protease inhibitor, Kazal type 1; Spink3; Tilp; trypsin inhibitor-like protein, pancreatic
Orthologs:
Homo sapiens (human) : SPINK1 (serine peptidase inhibitor, Kazal type 1)  HGNC  Alliance
Mus musculus (house mouse) : Spink1 (serine peptidase inhibitor, Kazal type 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Spink1 (serine peptidase inhibitor, Kazal type 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SPINK1 (serine peptidase inhibitor, Kazal type 1)
Canis lupus familiaris (dog) : SPINK1 (serine peptidase inhibitor, Kazal type 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Spink1 (serine peptidase inhibitor, Kazal type 1)
Sus scrofa (pig) : SPINK1 (serine peptidase inhibitor, Kazal type 1)
more info ...
Is Marker For: QTLs:   Bw11  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01838,221,919 - 38,242,092 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01837,878,841 - 37,898,259 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41837,135,503 - 37,148,282 (-)NCBIRGSC3.4rn4RGSC3.4
Cytogenetic Map18q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Spink1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3749
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.