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Gene: Srd5a1 (steroid 5 alpha-reductase 1) Rattus norvegicus
Symbol: Srd5a1
Name: steroid 5 alpha-reductase 1
Description: Exhibits 3-oxo-5-alpha-steroid 4-dehydrogenase activity; NADPH binding activity; and amide binding activity. Involved in several processes, including animal organ development; cellular hormone metabolic process; and cellular response to organic cyclic compound. Localizes to several cellular components, including cell body fiber; neuronal cell body; and perinuclear region of cytoplasm. Used to study prostate cancer. Biomarker of hyperprolactinemia; hypothyroidism; obesity; prostate cancer; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in prostate cancer and prostatic hypertrophy. Orthologous to human SRD5A1 (steroid 5 alpha-reductase 1); PARTICIPATES IN testosterone biosynthetic pathway; steroid hormone biosynthetic pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 3-oxo-5-alpha-steroid 4-dehydrogenase 1; MGC156498; S5AR 1; SR type 1; steroid 5-alpha-reductase 1; steroid-5-alpha-reductase 1; Steroid-5-alpha-reductase alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1); steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
Homo sapiens (human) : SRD5A1 (steroid 5 alpha-reductase 1)  HGNC  Alliance
Mus musculus (house mouse) : Srd5a1 (steroid 5 alpha-reductase 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Srd5a1 (steroid 5 alpha-reductase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SRD5A1 (steroid 5 alpha-reductase 1)
Canis lupus familiaris (dog) : SRD5A1 (steroid 5 alpha-reductase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Srd5a1 (steroid 5 alpha-reductase 1)
Sus scrofa (pig) : SRD5A1 (steroid 5 alpha-reductase 1)
Chlorocebus sabaeus (African green monkey) : SRD5A1 (steroid 5 alpha-reductase 1)
Heterocephalus glaber (naked mole-rat) : Srd5a1 (steroid 5 alpha-reductase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0136,320,504 - 36,354,694 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl136,320,461 - 36,354,756 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0137,717,526 - 37,751,716 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4173,845,190 - 3,879,165 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1173,845,345 - 3,877,557 (+)NCBI
Celera132,290,558 - 32,325,770 (+)NCBICelera
Cytogenetic Map1p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Srd5a1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3757
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.