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Gene: Syp (synaptophysin) Rattus norvegicus
Symbol: Syp
Name: synaptophysin
Description: Exhibits protein domain specific binding activity and syntaxin-1 binding activity. Involved in endocytosis; regulation of opioid receptor signaling pathway; and response to amyloid-beta. Localizes to several cellular components, including excitatory synapse; integral component of synaptic vesicle membrane; and postsynaptic density. Biomarker of Alzheimer's disease. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability. Orthologous to human SYP (synaptophysin); INTERACTS WITH (+)-pilocarpine; (S)-amphetamine; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: major synaptic vesicle protein p38; Syp1
Homo sapiens (human) : SYP (synaptophysin)  HGNC  Alliance
Mus musculus (house mouse) : Syp (synaptophysin)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Syp (synaptophysin)
Pan paniscus (bonobo/pygmy chimpanzee) : SYP (synaptophysin)
Canis lupus familiaris (dog) : SYP (synaptophysin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Syp (synaptophysin)
Sus scrofa (pig) : SYP (synaptophysin)
Chlorocebus sabaeus (African green monkey) : SYP (synaptophysin)
Heterocephalus glaber (naked mole-rat) : Syp (synaptophysin)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0X15,694,699 - 15,709,244 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX15,695,566 - 15,707,436 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X16,485,963 - 16,501,050 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X26,890,307 - 26,905,319 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X26,943,775 - 26,958,788 (-)NCBI
CeleraX14,932,808 - 14,947,852 (-)NCBICelera
Cytogenetic MapXq12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Syp
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3802
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.