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Gene: Hnf1a (HNF1 homeobox A) Rattus norvegicus
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Symbol: Hnf1a
Name: HNF1 homeobox A
Description: Exhibits DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and transcription cofactor binding activity. Involved in negative regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; and transcription by RNA polymerase II. Localizes to the nucleus. Biomarker of kidney disease. Human ortholog(s) of this gene implicated in glucose metabolism disease (multiple) and renal cell carcinoma. Orthologous to human HNF1A (HNF1 homeobox A); PARTICIPATES IN forkhead class A signaling pathway; maturity-onset diabetes of the young pathway; INTERACTS WITH (RS)-amphetamine; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: albumin proximal factor; hepatic nuclear factor 1; hepatic nuclear factor-1-alpha; hepatocyte nuclear factor 1-alpha; HNF-1-alpha; HNF-1A; HNF1; LF-B1; LF-B1 hepatic nuclear factor (HNF1): albumin proximal factor also TCF1; LF-B1, hepatic nuclear factor (HNF1): albumin proximal factor, also TCF1; Lfb1; liver-specific transcription factor LF-B1; TCF-1; Tcf1; transcription factor 1; Transcription factor 1 hepatic; Transcription factor 1, hepatic
Orthologs:
Homo sapiens (human) : HNF1A (HNF1 homeobox A)  HGNC  Alliance
Mus musculus (house mouse) : Hnf1a (HNF1 homeobox A)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hnf1a (HNF1 homeobox A)
Pan paniscus (bonobo/pygmy chimpanzee) : HNF1A (HNF1 homeobox A)
Canis lupus familiaris (dog) : HNF1A (HNF1 homeobox A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hnf1a (HNF1 homeobox A)
Sus scrofa (pig) : HNF1A (HNF1 homeobox A)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01247,407,811 - 47,433,342 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01249,195,096 - 49,226,754 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41242,919,574 - 42,945,670 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11242,782,961 - 42,809,058 (+)NCBI
Celera1243,263,411 - 43,289,196 (+)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Hnf1a
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3828
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-09-03
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.