Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Zeb1 (zinc finger E-box binding homeobox 1) Rattus norvegicus
Symbol: Zeb1
Name: zinc finger E-box binding homeobox 1
Description: Exhibits chromatin binding activity; double-stranded DNA binding activity; and sequence-specific DNA binding activity. Involved in several processes, including cellular response to transforming growth factor beta stimulus; regulation of transcription by RNA polymerase II; and response to activity. Localizes to nucleus. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy and posterior polymorphous corneal dystrophy 3. Orthologous to human ZEB1 (zinc finger E-box binding homeobox 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-acetamidofluorene; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: deltaEF1; TCF-8; Tcf8; Transcription factor 8; transcription factor 8 (represses interleukin 2 expression); zfhep; Zfhx1a; zinc finger E-box-binding homeobox 1; zinc finger homeodomain enhancer-binding protein
Homo sapiens (human) : ZEB1 (zinc finger E-box binding homeobox 1)  HGNC  Alliance
Mus musculus (house mouse) : Zeb1 (zinc finger E-box binding homeobox 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Zeb1 (zinc finger E-box binding homeobox 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ZEB1 (zinc finger E-box binding homeobox 1)
Canis lupus familiaris (dog) : ZEB1 (zinc finger E-box binding homeobox 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Zeb1 (zinc finger E-box binding homeobox 1)
Sus scrofa (pig) : ZEB1 (zinc finger E-box binding homeobox 1)
Chlorocebus sabaeus (African green monkey) : ZEB1 (zinc finger E-box binding homeobox 1)
Heterocephalus glaber (naked mole-rat) : Zeb1 (zinc finger E-box binding homeobox 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly; Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01754,656,627 - 54,714,920 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1754,658,463 - 54,714,914 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01752,353,064 - 52,373,420 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41760,177,150 - 60,198,584 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11760,187,896 - 60,245,300 (-)NCBI
Celera1747,960,914 - 48,019,394 (-)NCBICelera
Cytogenetic Map17q12.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Zeb1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3831
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.