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Gene: Tg (thyroglobulin) Rattus norvegicus
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Symbol: Tg
Name: thyroglobulin
Description: Exhibits several functions, including anion binding activity; chaperone binding activity; and identical protein binding activity. Involved in several processes, including response to lipopolysaccharide; thyroid hormone generation; and transcytosis. Localizes to several cellular components, including Golgi apparatus; endoplasmic reticulum; and perinuclear region of cytoplasm. Used to study hypothyroidism and isolated growth hormone deficiency. Human ortholog(s) of this gene implicated in Graves' disease; autoimmune thyroiditis; and goiter. Orthologous to human TG (thyroglobulin); PARTICIPATES IN thyroid hormone biosynthetic pathway; autoimmune thyroiditis pathway; INTERACTS WITH 2,2',4,4',5,5'-hexachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Tgn
Orthologs:
Homo sapiens (human) : TG (thyroglobulin)  HGNC  Alliance
Mus musculus (house mouse) : Tg (thyroglobulin)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tg (thyroglobulin)
Pan paniscus (bonobo/pygmy chimpanzee) : TG (thyroglobulin)
Canis lupus familiaris (dog) : TG (thyroglobulin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tg (thyroglobulin)
Sus scrofa (pig) : TG (thyroglobulin)
Chlorocebus sabaeus (African green monkey) : TG (thyroglobulin)
Heterocephalus glaber (naked mole-rat) : Tg (thyroglobulin)
more info ...
Allele / Splice: Tgrdw  
Genetic Models: WIC-Tgrdw/Kts
Is Marker For: Strains:   DWH/Iet  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.07107,467,260 - 107,652,897 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7107,467,260 - 107,652,899 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07107,399,165 - 107,602,400 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47104,035,776 - 104,220,754 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17104,070,005 - 104,254,984 (+)NCBI
Celera794,970,745 - 95,154,294 (+)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
Genetic Models
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Tg
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3848
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.