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Gene: Tle4 (TLE family member 4, transcriptional corepressor) Rattus norvegicus
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Symbol: Tle4
Name: TLE family member 4, transcriptional corepressor
Description: Predicted to have several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; repressing transcription factor binding activity; and transcription corepressor activity. Predicted to be involved in several processes, including cellular response to leukemia inhibitory factor; negative regulation of canonical Wnt signaling pathway; and negative regulation of transcription by RNA polymerase II. Localizes to nucleus. Orthologous to human TLE4 (TLE family member 4, transcriptional corepressor); INTERACTS WITH 2-ethoxyethanol; 2-methoxyethanol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Esp2; Grg-4; groucho-related protein 4; transducin-like enhancer of split 4; transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila); Transducin-like enhancer of split 4 homolog of Drosophila E(spl); transducin-like enhancer of split 4, E(spl) homolog; transducin-like enhancer of split 4, E(spl) homolog (Drosophila); transducin-like enhancer of split 4, homolog of Drosophila E(spl); transducin-like enhancer protein 4
Orthologs:
Homo sapiens (human) : TLE4 (TLE family member 4, transcriptional corepressor)  HGNC  Alliance
Mus musculus (house mouse) : Tle4 (transducin-like enhancer of split 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tle4 (TLE family member 4, transcriptional corepressor)
Pan paniscus (bonobo/pygmy chimpanzee) : TLE4 (TLE family member 4, transcriptional corepressor)
Canis lupus familiaris (dog) : TLE4 (TLE family member 4, transcriptional corepressor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tle4 (TLE family member 4, transcriptional corepressor)
Sus scrofa (pig) : TLE4 (TLE family member 4, transcriptional corepressor)
Chlorocebus sabaeus (African green monkey) : TLE4 (TLE family member 4, transcriptional corepressor)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01231,394,606 - 231,531,396 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1231,393,379 - 231,530,786 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01238,529,962 - 238,666,060 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41217,636,135 - 217,770,594 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11217,800,157 - 217,934,617 (-)NCBI
Celera1209,055,568 - 209,191,775 (-)NCBICelera
Cytogenetic Map1q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Tle4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3868
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.