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Gene: Tph1 (tryptophan hydroxylase 1) Rattus norvegicus
Symbol: Tph1
Name: tryptophan hydroxylase 1
CRRD ID: 3895
Description: Exhibits tryptophan 5-monooxygenase activity. Involved in circadian rhythm; negative regulation of ossification; and response to immobilization stress. Localizes to neuron projection. Biomarker of mental depression. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; borderline personality disorder; mental depression (multiple); and scoliosis. Orthologous to human TPH1 (tryptophan hydroxylase 1); PARTICIPATES IN tryptophan metabolic pathway; INTERACTS WITH 1,3,5-trinitro-1,3,5-triazinane; 4,4'-sulfonyldiphenol; 5-hydroxytryptophan.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Tph; tryptophan 5-hydroxylase 1; tryptophan 5-monooxygenase 1; tryptophan hydroxylase
Homo sapiens (human) : TPH1 (tryptophan hydroxylase 1)  HGNC  Alliance
Mus musculus (house mouse) : Tph1 (tryptophan hydroxylase 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tph1 (tryptophan hydroxylase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TPH1 (tryptophan hydroxylase 1)
Canis lupus familiaris (dog) : TPH1 (tryptophan hydroxylase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tph1 (tryptophan hydroxylase 1)
Sus scrofa (pig) : TPH1 (tryptophan hydroxylase 1)
Chlorocebus sabaeus (African green monkey) : TPH1 (tryptophan hydroxylase 1)
Heterocephalus glaber (naked mole-rat) : Tph1 (tryptophan hydroxylase 1)
more info ...
Allele / Splice: Tph1em1Mcwi   Tph1em3Mcwi   Tph1em4Mcwi  
Genetic Models: WKY-Tph1em1Mcwi DA-Tph1em4Mcwi WKY-Tph1em3Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01102,669,868 - 102,699,442 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1102,669,868 - 102,699,442 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01103,746,878 - 103,774,100 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4197,186,071 - 97,207,551 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1197,264,181 - 97,285,662 (-)NCBI
Celera191,404,769 - 91,425,505 (-)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Tph1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3895
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.