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Gene: Tpo (thyroid peroxidase) Rattus norvegicus
Symbol: Tpo
Name: thyroid peroxidase
CRRD ID: 3900
Description: Predicted to have iodide peroxidase activity. Involved in cellular response to nitric oxide and response to lipid. Localizes to cell surface and plasma membrane. Human ortholog(s) of this gene implicated in congenital hypothyroidism and glomerulonephritis. Orthologous to human TPO (thyroid peroxidase); PARTICIPATES IN thyroid hormone biosynthetic pathway; autoimmune thyroiditis pathway; cytokine mediated signaling pathway; INTERACTS WITH (S)-naringenin; 1,3-benzothiazole-2-thiol; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: truncated thyroid peroxidase
Homo sapiens (human) : TPO (thyroid peroxidase)  HGNC  Alliance
Mus musculus (house mouse) : Tpo (thyroid peroxidase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tpo (thyroid peroxidase)
Pan paniscus (bonobo/pygmy chimpanzee) : TPO (thyroid peroxidase)
Canis lupus familiaris (dog) : TPO (thyroid peroxidase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tpo (thyroid peroxidase)
Sus scrofa (pig) : TPO (thyroid peroxidase)
Chlorocebus sabaeus (African green monkey) : TPO (thyroid peroxidase)
Heterocephalus glaber (naked mole-rat) : Tpo (thyroid peroxidase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0649,020,918 - 49,089,855 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl649,021,044 - 49,089,855 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0657,702,091 - 57,770,914 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4647,954,848 - 48,025,740 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1647,957,973 - 48,028,866 (-)NCBI
Celera645,906,515 - 45,971,940 (-)NCBICelera
Cytogenetic Map6q16NCBI
RH 3.4 Map6299.2RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Tpo
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3900
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.