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Gene: Trhr (thyrotropin releasing hormone receptor) Rattus norvegicus
Symbol: Trhr
Name: thyrotropin releasing hormone receptor
Description: Exhibits identical protein binding activity and thyrotropin-releasing hormone receptor activity. Involved in positive regulation of cytosolic calcium ion concentration and positive regulation of protein-containing complex assembly. Localizes to cell surface. Used to study hypertension. Human ortholog(s) of this gene implicated in congenital hypothyroidism and hypertension. Orthologous to human TRHR (thyrotropin releasing hormone receptor); PARTICIPATES IN calcium/calcium-mediated signaling pathway; INTERACTS WITH (+)-pilocarpine; 2,2',4,4',5,5'-hexachlorobiphenyl; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: thyroliberin receptor; thyrotropin-releasing hormone receptor; TRH-R
Homo sapiens (human) : TRHR (thyrotropin releasing hormone receptor)  HGNC  Alliance
Mus musculus (house mouse) : Trhr (thyrotropin releasing hormone receptor)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Trhr (thyrotropin releasing hormone receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : TRHR (thyrotropin releasing hormone receptor)
Canis lupus familiaris (dog) : TRHR (thyrotropin releasing hormone receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Trhr (thyrotropin releasing hormone receptor)
Sus scrofa (pig) : TRHR (thyrotropin releasing hormone receptor)
Chlorocebus sabaeus (African green monkey) : TRHR (thyrotropin releasing hormone receptor)
Heterocephalus glaber (naked mole-rat) : Trhr (thyrotropin releasing hormone receptor)
more info ...
Is Marker For: Strains:   SS.LEW-(D7Rat73-D7Rat128)/Ayd   LEW.SS-(D7Rat73-D7Rat128)/Ayd  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0783,113,641 - 83,153,520 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl783,113,672 - 83,153,519 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0783,121,134 - 83,161,215 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4780,050,671 - 80,095,991 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1780,071,435 - 80,116,717 (+)NCBI
Celera772,334,405 - 72,378,742 (+)NCBICelera
Cytogenetic Map7q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Trhr
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3904
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-05-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.