LOC109611590 (Runx2 P1 promoter region) - Chinchilla Research Resource Database
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Gene: LOC109611590 (Runx2 P1 promoter region) Mus musculus
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Symbol: LOC109611590
Name: Runx2 P1 promoter region
CRRD ID: 39130132
Description: This region represents the P1 promoter of the runt related transcription factor 2 (Runx2) gene, and is able to drives expression of a reporter transgene in bone and testis. Bone morphogenetic protein 2 stimulates activation of this sequence through chromatin changes that result in the creation of a DNase I hypersensitive region in the proximal promoter. This region is autoregulated through binding by Runx2 to multiple conserved recognition sites. An element encompassing an AP1 binding site functions as an enhancer of promoter activity. This promoter is further regulated by binding of homeobox A10 and distal-less homeobox 5 to multiple distal homeodomain binding sites. Signaling by vitamin D3 and transforming growth factor beta may negatively regulate promoter activity. [provided by RefSeq, Jan 2017]
Type: biological-region
RefSeq Status: REVIEWED
Orthologs:
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391745,125,132 - 45,128,989 (+)NCBI
GRCm381744,814,245 - 44,818,102 (+)NCBIGRCm38GRCm38mm10GRCm38
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References
Additional References at PubMed
PMID:9238031   PMID:9651525   PMID:10215629   PMID:10514508   PMID:10524201   PMID:10907848   PMID:10911365   PMID:11331591   PMID:11500942   PMID:11723115   PMID:11900492   PMID:12112009  
PMID:12175505   PMID:12186862   PMID:12682904   PMID:12704187   PMID:12890574   PMID:15156175   PMID:15174088   PMID:15703179   PMID:15838892   PMID:16043491   PMID:16115867   PMID:16786196  
PMID:17325044   PMID:17439743   PMID:17579210   PMID:18321855   PMID:18442887   PMID:19017640   PMID:19545172   PMID:20215006   PMID:21302301   PMID:21676869   PMID:22093831   PMID:22886425  
PMID:23438432   PMID:24355298   PMID:24520423   PMID:24692107   PMID:24881813   PMID:25120271   PMID:25205373   PMID:25802132   PMID:26453309   PMID:27916785  


Genomics

Comparative Map Data
LOC109611590
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391745,125,132 - 45,128,989 (+)NCBI
GRCm381744,814,245 - 44,818,102 (+)NCBIGRCm38GRCm38mm10GRCm38
LOC109611593
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38645,327,048 - 45,328,652 (+)NCBIGRCh38GRCh38hg38GRCh38


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
CRRD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300890Bhr3_mbronchial hyperresponsiveness 3 (mouse)Not determined17392461548559063Mouse
4141215Mnic1_mmacronutrient intake, carbohydrate 1 (mouse)Not determined480447745359340Mouse
1300706Alan1_malloantigen response 1 (mouse)Not determined17480447746158776Mouse
1357789Kdnw3_mkidney weight 3 (mouse)Not determined17480447747574740Mouse
4141272Tfv1_mtotal food volume 1 (mouse)Not determined480447765330362Mouse
1301338Lmr1_mleishmaniasis resistance 1 (mouse)Not determined17986241186688972Mouse
4141067Hbnr2_mHeligmosomoides bakeri nematode resistance 2 (mouse)Not determined1166699745667145Mouse
14747010Mancz14_mmandible centroid size 14 (mouse)171177921045779210Mouse
4142150Stheal11_msoft tissue heal 11 (mouse)Not determined171206732483054339Mouse
12904946Tammq8_mtibialis anterior muscle mass QTL 8 (mouse)171223281346232813Mouse
13524847Asrq8a_macoustic startle response 8a (mouse)171242798746427987Mouse
11081168Tir7_mtrypanosome infection response 7 (mouse)171390439847904522Mouse
1300914Pcir4_mperiosteal circumference 4 (mouse)Not determined171484267848842786Mouse
1558886Lgth9_mbody length 9 (mouse)Not determined171484267848842786Mouse
1302070Tbbmd7_mtotal body bone mineral density 7 (mouse)Not determined171484267848842786Mouse
1300995Fembrs4_mfemur breaking strength 4 (mouse)Not determined171484267848842786Mouse
1302140Wta4_mweight adult 4 (mouse)Not determined171660074750600869Mouse
1302152Skull25_mskull morphology 25 (mouse)Not determined171660074750600869Mouse
1301505Tir1_mtrypanosome infection response 1 (mouse)Not determined171660074750600869Mouse
10412083Sm2_msusceptibility to Schistosoma mansoni infection 2 (mouse)Not determined171681096950811104Mouse
1302042Acsns3_mAngiostrongylus costaricensis nematode susceptibility 3 (mouse)Not determined171724323451243371Mouse
1300535Char3_mP. chabaudi malaria resistance QTL 3 (mouse)Not determined171724323451243371Mouse
10412214Sxbq3_mSGC/Knj cross B6 QTL 3 (mouse)Not determined171724323451243371Mouse
13452396Leusq3_mleucocytosis susceptibility QTL 3 (mouse)171724323451243371Mouse
13452399Leusq6_mleucocytosis susceptibility QTL 6 (mouse)171724323451243371Mouse
1301840Ssial4_msusceptibility to sialadenitiss 4 (mouse)Not determined171795643651959238Mouse
1301331Lbw1_mlupus NZB x NZW 1 (mouse)Not determined171819938152202007Mouse
1301056Pas2_mpulmonary adenoma susceptibility 2 (mouse)Not determined171820316552205351Mouse
15039354Nmrs36_mNAFLD-associated magnetic resonance shift 36 (mouse)171883413352834133Mouse
1301454Eae5_msusceptibility to experimental allergic encephalomyelitis 5 (mouse)Not determined172430185958301973Mouse
10412198Sst5_msusceptibility to tuberculosis 5 (mouse)Not determined172485760955405969Mouse
10412204Bbaa29_mB.burgdorferi-associated arthritis 29 (mouse)Not determined172574029459740461Mouse
1558758Kcal2_mkilocalorie 2 (mouse)Not determined172618203852604676Mouse
1302005Loco2_mlocomotor activity 2 (mouse)Not determined172657408160574223Mouse
11075105Modc1_mmodifier of Odc1 (mouse)172749681845311728Mouse
15039348Nmrs37_mNAFLD-associated magnetic resonance shift 37 (mouse)172750432261504322Mouse
1300703Uvbi2_mUVB induced immunosuppression 2 (mouse)Not determined172831148062311728Mouse
1300589Myaa2_mmodifier of Yaa 2 (mouse)Not determined172982162963821740Mouse
4140955Plgr1_mplague resistance locus 1 (mouse)Not determined3072257564722705Mouse
4141357Mrdq1_mmodifier of retinal degeneration QTL 1 (mouse)Not determined3076892947728778Mouse
26884379Skwq5_mskull length QTL 5, 5 week (mouse)173290000053800000Mouse
1300885Mbis4_mMycobacterium bovis-induced systemic lupus erythematosus 4 (mouse)Not determined173495684169858931Mouse
10755514Amzn2_manatomical modifier of Zfp423 2 (mouse)173565926669659396Mouse
12904951Smmq2_msoleus muscle mass QTL 2 (mouse)173648271570482715Mouse
1301474Hcbip2_mhexachlorobenzene induced porphyria 2 (mouse)Not determined173748216445311728Mouse
1300592Pcyts5_mplasmacytoma susceptibility 5 (mouse)Not determined173840588672405969Mouse
10755525Lymph2_mlymphocyte differential 2 (mouse)173849862572498625Mouse
10755534Lymph4_mlymphocyte differential 4 (mouse)173849862572498625Mouse
4141319Hmtb8_mhemostasis and thrombosis rebleeding time 8 (mouse)Not determined4022744774227623Mouse
15039324Nmrs48_mNAFLD-associated magnetic resonance shift 48 (mouse)174063218774632187Mouse
4141478Hbnr7_mHeligmosomoides bakeri nematode resistance 7 (mouse)Not determined4274029451432094Mouse
25394539Skmw85_mskeletal muscle weight 85, gastroc (mouse)174339677746521031Mouse
26884386Skwq13_mskull length QTL 13, 16 week (mouse)174340000052800000Mouse
26884390Skwq9_mskull length QTL 9, 10 week (mouse)174340000067500000Mouse
12903997Cfq4_mconditioned fear QTL 4 (mouse)174470566549059374Mouse


Expression


Sequence



Additional Information

Database Acc Id Source(s)
NCBI Gene LOC109611590 ENTREZGENE
PhenoGen LOC109611590 PhenoGen