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Gene: Ttr (transthyretin) Rattus norvegicus
Symbol: Ttr
Name: transthyretin
Description: Exhibits hormone binding activity. Predicted to be involved in purine nucleobase metabolic process. Localizes to extracellular space and protein-containing complex. Biomarker of brain ischemia. Human ortholog(s) of this gene implicated in Alzheimer's disease; amyloidosis; carpal tunnel syndrome; dystransthyretinemic hyperthyroxinemia; and transthyretin amyloidosis. Orthologous to human TTR (transthyretin); PARTICIPATES IN forkhead class A signaling pathway; retinoic acid metabolic pathway; INTERACTS WITH (+)-schisandrin B; 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: LR1; prealbumin; prealbumin, amyloidosis type I; Tbpa; Transthyretin (prealbumin amyloidosis type I); Transthyretin (prealbumin, amyloidosis type I); TT
Homo sapiens (human) : TTR (transthyretin)  HGNC  Alliance
Mus musculus (house mouse) : Ttr (transthyretin)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ttr (transthyretin)
Pan paniscus (bonobo/pygmy chimpanzee) : TTR (transthyretin)
Canis lupus familiaris (dog) : TTR (transthyretin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ttr (transthyretin)
Sus scrofa (pig) : TTR (transthyretin)
Chlorocebus sabaeus (African green monkey) : TTR (transthyretin)
Heterocephalus glaber (naked mole-rat) : Ttr (transthyretin)
more info ...
Is Marker For: QTLs:   Bp46   Scl22  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01815,532,963 - 15,542,180 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1815,532,963 - 15,540,177 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01815,307,563 - 15,316,780 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41812,406,571 - 12,413,680 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11812,433,216 - 12,440,326 (+)NCBI
Celera1811,951,406 - 11,958,617 (+)NCBICelera
Cytogenetic Map18p12NCBI
RH 3.4 Map1891.82RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Ttr
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3916
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.