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Gene: Ttr (transthyretin) Rattus norvegicus
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Symbol: Ttr
Name: transthyretin
Description: Exhibits hormone binding activity. Predicted to be involved in purine nucleobase metabolic process. Localizes to extracellular space and protein-containing complex. Biomarker of brain ischemia. Human ortholog(s) of this gene implicated in Alzheimer's disease; amyloidosis; carpal tunnel syndrome; dystransthyretinemic hyperthyroxinemia; and transthyretin amyloidosis. Orthologous to human TTR (transthyretin); PARTICIPATES IN forkhead class A signaling pathway; retinoic acid metabolic pathway; INTERACTS WITH (+)-schisandrin B; 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: LR1; prealbumin; prealbumin, amyloidosis type I; Tbpa; Transthyretin (prealbumin amyloidosis type I); Transthyretin (prealbumin, amyloidosis type I); TT
Orthologs:
Homo sapiens (human) : TTR (transthyretin)  HGNC  Alliance
Mus musculus (house mouse) : Ttr (transthyretin)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ttr (transthyretin)
Pan paniscus (bonobo/pygmy chimpanzee) : TTR (transthyretin)
Canis lupus familiaris (dog) : TTR (transthyretin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ttr (transthyretin)
Sus scrofa (pig) : TTR (transthyretin)
Chlorocebus sabaeus (African green monkey) : TTR (transthyretin)
Heterocephalus glaber (naked mole-rat) : Ttr (transthyretin)
more info ...
Is Marker For: QTLs:   Bp46   Scl22  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01815,532,963 - 15,542,180 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1815,532,963 - 15,540,177 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01815,307,563 - 15,316,780 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41812,406,571 - 12,413,680 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11812,433,216 - 12,440,326 (+)NCBI
Celera1811,951,406 - 11,958,617 (+)NCBICelera
Cytogenetic Map18p12NCBI
RH 3.4 Map1891.82RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Ttr
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3916
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.