Gene: Tyms (thymidylate synthetase) Rattus norvegicus
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Symbol: Tyms
Name: thymidylate synthetase
Description: Exhibits several functions, including cofactor binding activity, folic acid binding activity, and mRNA binding activity; involved in several processes, including animal organ development, nucleobase-containing small molecule metabolic process, and response to steroid hormone; localizes to the mitochondrion and nucleolus; used to study urinary bladder cancer; biomarker of colorectal adenocarcinoma; orthologous to human TYMS (thymidylate synthetase); PARTICIPATES IN folate mediated one-carbon metabolic pathway; folate metabolic pathway; pyrimidine metabolic pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: MGC156654; thymidylate synthase; TS; TSase
Orthologs:
Homo sapiens (human) : TYMS (thymidylate synthetase)  HGNC  Alliance
Mus musculus (house mouse) : Tyms (thymidylate synthase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tyms (thymidylate synthetase)
Pan paniscus (bonobo/pygmy chimpanzee) : TYMS (thymidylate synthetase)
Canis lupus familiaris (dog) : TYMS (thymidylate synthetase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tyms (thymidylate synthetase)
Sus scrofa (pig) : TYMS (thymidylate synthetase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.09121,918,875 - 121,931,564 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.09121,368,418 - 121,381,493 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.49112,604,912 - 112,617,706 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.19112,814,399 - 112,827,186 (-)NCBI
Celera9110,420,900 - 110,433,600 (-)NCBICelera
Cytogenetic Map9q38NCBI
RH 3.4 Map9866.0RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Tyms
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3921
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.