Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Uchl1 (ubiquitin C-terminal hydrolase L1) Rattus norvegicus
Symbol: Uchl1
Name: ubiquitin C-terminal hydrolase L1
Description: Predicted to have several functions, including alpha-2A adrenergic receptor binding activity; peptidase activity, acting on L-amino acid peptides; and ubiquitin protein ligase binding activity. Involved in sensory perception of pain and ubiquitin-dependent protein catabolic process. Predicted to colocalize with plasma membrane. Biomarker of retinal disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; hereditary spastic paraplegia; and late onset Parkinson's disease. Orthologous to human UCHL1 (ubiquitin C-terminal hydrolase L1); PARTICIPATES IN Parkinson's disease pathway; INTERACTS WITH 1,3-dinitrobenzene; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
Also known as: neuron cytoplasmic protein 9.5; PGP 9.5; PGP9.5; ubiquitin carboxy-terminal hydrolase L1; ubiquitin carboxyl-terminal esterase L1; ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase); ubiquitin carboxyl-terminal hydrolase isozyme L1; ubiquitin thioesterase L1; UCH-L1
Homo sapiens (human) : UCHL1 (ubiquitin C-terminal hydrolase L1)  HGNC  Alliance
Mus musculus (house mouse) : Uchl1 (ubiquitin carboxy-terminal hydrolase L1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Uchl1 (ubiquitin C-terminal hydrolase L1)
Pan paniscus (bonobo/pygmy chimpanzee) : UCHL1 (ubiquitin C-terminal hydrolase L1)
Canis lupus familiaris (dog) : UCHL1 (ubiquitin C-terminal hydrolase L1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Uchl1 (ubiquitin C-terminal hydrolase L1)
Sus scrofa (pig) : UCHL1 (ubiquitin C-terminal hydrolase L1)
Chlorocebus sabaeus (African green monkey) : UCHL1 (ubiquitin C-terminal hydrolase L1)
Heterocephalus glaber (naked mole-rat) : Uchl1 (ubiquitin C-terminal hydrolase L1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01443,133,224 - 43,143,942 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1443,133,218 - 43,143,973 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01442,928,247 - 42,938,981 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41444,114,392 - 44,124,947 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11444,116,782 - 44,127,338 (-)NCBI
Celera1440,639,549 - 40,650,302 (-)NCBICelera
Cytogenetic Map14p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Uchl1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3928
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-05-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.