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Gene: Ucp1 (uncoupling protein 1) Rattus norvegicus
Symbol: Ucp1
Name: uncoupling protein 1
CRRD ID: 3931
Description: Exhibits GDP binding activity; GTP binding activity; and oxidative phosphorylation uncoupler activity. Involved in several processes, including cellular response to hormone stimulus; cellular response to lipid; and mitochondrial transmembrane transport. Localizes to mitochondrion. Biomarker of prediabetes syndrome. Human ortholog(s) of this gene implicated in hypertension and type 2 diabetes mellitus. Orthologous to human UCP1 (uncoupling protein 1); PARTICIPATES IN eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; Huntington's disease pathway; INTERACTS WITH (+)-taxifolin; (R)-noradrenaline; (S)-naringenin.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: MGC108736; mitochondrial brown fat uncoupling protein 1; solute carrier family 25 member 7; thermogenin; Ucp; UCP 1; Ucpa; Uncoupling protein; uncoupling protein 1 (mitochondrial, proton carrier); uncoupling protein 1 mitochondrial; uncoupling protein 1, mitochondrial; Uncp
Homo sapiens (human) : UCP1 (uncoupling protein 1)  HGNC  Alliance
Mus musculus (house mouse) : Ucp1 (uncoupling protein 1 (mitochondrial, proton carrier))  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ucp1 (uncoupling protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : UCP1 (uncoupling protein 1)
Canis lupus familiaris (dog) : UCP1 (uncoupling protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ucp1 (uncoupling protein 1)
Sus scrofa (pig) : UCP1 (uncoupling protein 1)
Chlorocebus sabaeus (African green monkey) : UCP1 (uncoupling protein 1)
Heterocephalus glaber (naked mole-rat) : Ucp1 (uncoupling protein 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01924,456,976 - 24,464,808 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1924,456,976 - 24,464,807 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01935,434,980 - 35,442,812 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41926,527,548 - 26,535,621 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11926,532,373 - 26,540,447 (-)NCBI
Celera1924,348,444 - 24,356,517 (-)NCBICelera
Cytogenetic Map19q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Ucp1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3931
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.