Gene: Ucp2 (uncoupling protein 2) Rattus norvegicus
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Symbol: Ucp2
Name: uncoupling protein 2
Description: Predicted to have oxidative phosphorylation uncoupler activity; involved in several processes, including aging, cellular response to amino acid starvation, and cellular response to glucose stimulus; localizes to the mitochondrion; used to study hypertension, nonalcoholic fatty liver disease, transient cerebral ischemia, and type 2 diabetes mellitus; biomarker of congestive heart failure, fatty liver disease (multiple), hypothyroidism, obstructive jaundice, and type 2 diabetes mellitus; orthologous to human UCP2 (uncoupling protein 2); PARTICIPATES IN forkhead class A signaling pathway; INTERACTS WITH (+)-catechin; (R)-lipoic acid; (R)-noradrenaline.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: mitochondrial uncoupling protein 2; solute carrier family 25 member 8; UCP 2; uncoupling protein 2 (mitochondrial, proton carrier); Uncoupling protein 2 mitochondrial; Uncoupling protein 2, mitochondrial
Orthologs:
Homo sapiens (human) : UCP2 (uncoupling protein 2)  HGNC  Alliance
Mus musculus (house mouse) : Ucp2 (uncoupling protein 2 (mitochondrial, proton carrier))  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ucp2 (uncoupling protein 2)
Pan paniscus (bonobo/pygmy chimpanzee) : UCP2 (uncoupling protein 2)
Canis lupus familiaris (dog) : UCP2 (uncoupling protein 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ucp2 (uncoupling protein 2)
Sus scrofa (pig) : UCP2 (uncoupling protein 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01165,506,375 - 165,512,744 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01171,707,625 - 171,713,991 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41157,925,514 - 157,928,222 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11158,000,971 - 158,007,311 (+)NCBI
Celera1152,922,529 - 152,928,898 (+)NCBICelera
Cytogenetic Map1q32NCBI
RH 3.4 Map11261.4RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Ucp2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3932
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.