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Gene: Vav1 (vav guanine nucleotide exchange factor 1) Rattus norvegicus
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Symbol: Vav1
Name: vav guanine nucleotide exchange factor 1
Description: Predicted to have Rac guanyl-nucleotide exchange factor activity and phosphotyrosine residue binding activity. Involved in immune response-regulating cell surface receptor signaling pathway. Predicted to localize to the cell-cell junction. Biomarker of endometriosis; hepatocellular carcinoma; lymphopenia; and type 1 diabetes mellitus. Orthologous to human VAV1 (vav guanine nucleotide exchange factor 1); PARTICIPATES IN interleukin-6 signaling pathway; B cell receptor signaling pathway; chemokine mediated signaling pathway; INTERACTS WITH 6-propyl-2-thiouracil; ammonium chloride; N-nitrosodiethylamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: p95; proto-oncogene vav; Vav; vav 1 guanine nucleotide exchange factor; Vav 1 oncogene
Orthologs:
Homo sapiens (human) : VAV1 (vav guanine nucleotide exchange factor 1)  HGNC  Alliance
Mus musculus (house mouse) : Vav1 (vav 1 oncogene)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Vav1 (vav guanine nucleotide exchange factor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : VAV1 (vav guanine nucleotide exchange factor 1)
Canis lupus familiaris (dog) : VAV1 (vav guanine nucleotide exchange factor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Vav1 (vav guanine nucleotide exchange factor 1)
Sus scrofa (pig) : VAV1 (vav guanine nucleotide exchange factor 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly; Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.099,617,551 - 9,675,167 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.098,626,445 - 8,655,152 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.098,682,235 - 8,682,495 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera96,313,197 - 6,360,060 (-)NCBICelera
Cytogenetic Map9q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Vav1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3951
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.