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Gene: Vhl (von Hippel-Lindau tumor suppressor) Rattus norvegicus
Symbol: Vhl
Name: von Hippel-Lindau tumor suppressor
Description: Predicted to contribute to ubiquitin-protein transferase activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; regulation of catecholamine metabolic process; and response to ethanol. Localizes to several cellular components, including VCB complex; cytosol; and mitochondrion. Biomarker of nephroblastoma and urinary bladder cancer. Human ortholog(s) of this gene implicated in several diseases, including pancreatic cancer (multiple); pheochromocytoma; polycythemia (multiple); renal cell carcinoma; and von Hippel-Lindau disease. Orthologous to several human genes including VHL (von Hippel-Lindau tumor suppressor); PARTICIPATES IN hypoxia inducible factor pathway; altered hypoxia inducible factor pathway; proteasome degradation pathway involving cullin-dependent ubiquitin ligases; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,6-dinitrotoluene.
Type: protein-coding
Also known as: pVHL; Vhlh; von Hippel-Lindau disease tumor suppressor; von Hippel-Lindau syndrome; von Hippel-Lindau syndrome homolog; von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
Homo sapiens (human) : VHL (von Hippel-Lindau tumor suppressor)  HGNC  Alliance
Mus musculus (house mouse) : Vhl (von Hippel-Lindau tumor suppressor)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Vhl (von Hippel-Lindau tumor suppressor)
Pan paniscus (bonobo/pygmy chimpanzee) : VHL (von Hippel-Lindau tumor suppressor)
Canis lupus familiaris (dog) : VHL (von Hippel-Lindau tumor suppressor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Vhl (von Hippel-Lindau tumor suppressor)
Sus scrofa (pig) : VHL (von Hippel-Lindau tumor suppressor)
Chlorocebus sabaeus (African green monkey) : VHL (von Hippel-Lindau tumor suppressor)
Heterocephalus glaber (naked mole-rat) : Vhl (von Hippel-Lindau tumor suppressor)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.04145,580,869 - 145,587,835 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4145,580,799 - 145,587,845 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04208,877,266 - 208,884,234 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44149,529,396 - 149,536,289 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14149,774,236 - 149,781,130 (+)NCBI
Celera4135,326,806 - 135,333,699 (+)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Vhl
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3960
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-03-31
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.