Gene: Vhl (von Hippel-Lindau tumor suppressor) Rattus norvegicus
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Symbol: Vhl
Name: von Hippel-Lindau tumor suppressor
Description: Predicted to contribute to ubiquitin-protein transferase activity; involved in several processes, including negative regulation of transcription by RNA polymerase II, neuron differentiation, and protein heterooligomerization; localizes to several cellular components, including the cytoplasm and intracellular membrane-bounded organelle; biomarker of nephroblastoma and urinary bladder cancer; orthologous to several human genes including VHL (von Hippel-Lindau tumor suppressor); PARTICIPATES IN hypoxia inducible factor pathway; altered hypoxia inducible factor pathway; proteasome degradation pathway involving cullin-dependent ubiquitin ligases; INTERACTS WITH 17alpha-ethynylestradiol; 2,6-dinitrotoluene; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: pVHL; Vhlh; von Hippel-Lindau disease tumor suppressor; von Hippel-Lindau syndrome; von Hippel-Lindau syndrome homolog; von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
Orthologs:
Homo sapiens (human) : VHL (von Hippel-Lindau tumor suppressor)  HGNC  Alliance
Mus musculus (house mouse) : Vhl (von Hippel-Lindau tumor suppressor)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Vhl (von Hippel-Lindau tumor suppressor)
Pan paniscus (bonobo/pygmy chimpanzee) : VHL (von Hippel-Lindau tumor suppressor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Vhl (von Hippel-Lindau tumor suppressor)
Sus scrofa (pig) : VHL (von Hippel-Lindau tumor suppressor)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.04145,580,869 - 145,587,835 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04208,877,266 - 208,884,234 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44149,529,396 - 149,536,289 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14149,774,236 - 149,781,130 (+)NCBI
Celera4135,326,806 - 135,333,699 (+)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Vhl
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3960
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.