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Gene: Zap70 (zeta chain of T cell receptor associated protein kinase 70) Rattus norvegicus
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Symbol: Zap70
Name: zeta chain of T cell receptor associated protein kinase 70
Description: Predicted to have ATP binding activity; phosphotyrosine residue binding activity; and protein tyrosine kinase activity. Predicted to be involved in several processes, including T cell selection; cellular protein modification process; and positive regulation of alpha-beta T cell activation. Predicted to colocalize with the membrane raft. Human ortholog(s) of this gene implicated in primary immunodeficiency disease and severe combined immunodeficiency. Orthologous to human ZAP70 (zeta chain of T cell receptor associated protein kinase 70); PARTICIPATES IN phosphatidylinositol 3-kinase class I signaling pathway; primary immunodeficiency pathway; T cell receptor signaling pathway; INTERACTS WITH (RS)-amphetamine; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: MGC108902; Srk; syk-related protein tyrosine kinase; tyrosine-protein kinase ZAP-70; Zap70_mapped; zeta-chain (TCR) associated protein kinase; zeta-chain (TCR) associated protein kinase 70; zeta-chain (TCR) associated protein kinase 70 (mapped); zeta-chain (TCR) associated protein kinase 70kDa
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0943,331,149 - 43,353,097 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0942,980,050 - 43,002,015 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4935,693,089 - 35,715,071 (+)NCBIRGSC3.4rn4RGSC3.4
Celera936,755,106 - 36,777,088 (+)NCBICelera
Cytogenetic Map9q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Zap70
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3983
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.