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Gene: Zap70 (zeta chain of T cell receptor associated protein kinase 70) Rattus norvegicus
Symbol: Zap70
Name: zeta chain of T cell receptor associated protein kinase 70
Description: Predicted to have ATP binding activity; non-membrane spanning protein tyrosine kinase activity; and phosphotyrosine residue binding activity. Predicted to be involved in several processes, including T cell selection; positive regulation of alpha-beta T cell activation; and protein phosphorylation. Predicted to colocalize with membrane raft. Human ortholog(s) of this gene implicated in primary immunodeficiency disease and severe combined immunodeficiency. Orthologous to human ZAP70 (zeta chain of T cell receptor associated protein kinase 70); PARTICIPATES IN phosphatidylinositol 3-kinase class I signaling pathway; primary immunodeficiency pathway; T cell receptor signaling pathway; INTERACTS WITH (+)-schisandrin B; 2,3,4,7,8-Pentachlorodibenzofuran; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
Also known as: MGC108902; Srk; syk-related protein tyrosine kinase; tyrosine-protein kinase ZAP-70; Zap70_mapped; zeta-chain (TCR) associated protein kinase; zeta-chain (TCR) associated protein kinase 70; zeta-chain (TCR) associated protein kinase 70 (mapped); zeta-chain (TCR) associated protein kinase 70kDa
Homo sapiens (human) : ZAP70 (zeta chain of T cell receptor associated protein kinase 70)  HGNC  Alliance
Mus musculus (house mouse) : Zap70 (zeta-chain (TCR) associated protein kinase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Zap70 (zeta-chain (TCR) associated protein kinase 70kDa)
Pan paniscus (bonobo/pygmy chimpanzee) : LOC100971372 (tyrosine-protein kinase ZAP-70)
Canis lupus familiaris (dog) : ZAP70 (zeta chain of T cell receptor associated protein kinase 70)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101971458 (tyrosine-protein kinase ZAP-70)
Sus scrofa (pig) : ZAP70 (zeta chain of T cell receptor associated protein kinase 70)
Chlorocebus sabaeus (African green monkey) : ZAP70 (zeta-chain (TCR) associated protein kinase 70kDa)
Heterocephalus glaber (naked mole-rat) : LOC101716577 (tyrosine-protein kinase ZAP-70)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0943,331,149 - 43,353,097 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl943,331,155 - 43,353,113 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0942,980,050 - 43,002,015 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4935,693,089 - 35,715,071 (+)NCBIRGSC3.4rn4RGSC3.4
Celera936,755,106 - 36,777,088 (+)NCBICelera
Cytogenetic Map9q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Zap70
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 3983
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.