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Gene: Crhr1 (corticotropin releasing hormone receptor 1) Rattus norvegicus
Symbol: Crhr1
Name: corticotropin releasing hormone receptor 1
Description: Exhibits several functions, including G-protein alpha-subunit binding activity; corticotropin-releasing hormone binding activity; and corticotropin-releasing hormone receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; learning or memory; and regulation of secretion by cell. Localizes to several cellular components, including multivesicular body; neuronal cell body; and trans-Golgi network. Used to study hypertension. Biomarker of functional colonic disease; irritable bowel syndrome; mental depression; thromboangiitis obliterans; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; and obesity. Orthologous to several human genes including LINC02210-CRHR1 (LINC02210-CRHR1 readthrough); PARTICIPATES IN corticotropin-releasing hormone signaling pathway; G protein mediated signaling pathway via Galphas family; long term depression; INTERACTS WITH (R)-noradrenaline; 2,4,6-trinitrobenzenesulfonic acid; ammonium chloride.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: Corticotrophin releasing hormone receptor 1; corticotropin releasing hormone 1; corticotropin-releasing factor receptor 1; corticotropin-releasing hormone receptor 1; CRF-R; CRF-R-1; CRF-R1; CRF1; CRFR-1; CRFR1; CRH-R 1; CRH-R-1; CRH-R1
Homo sapiens (human) : CRHR1 (corticotropin releasing hormone receptor 1)  HGNC  Alliance
Mus musculus (house mouse) : Crhr1 (corticotropin releasing hormone receptor 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Crhr1 (corticotropin releasing hormone receptor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : CRHR1 (corticotropin releasing hormone receptor 1)
Canis lupus familiaris (dog) : LOC610380 (corticotropin-releasing factor receptor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Crhr1 (corticotropin releasing hormone receptor 1)
Sus scrofa (pig) : CRHR1 (corticotropin releasing hormone receptor 1)
Chlorocebus sabaeus (African green monkey) : CRHR1 (corticotropin releasing hormone receptor 1)
Heterocephalus glaber (naked mole-rat) : Crhr1 (corticotropin releasing hormone receptor 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01092,191,473 - 92,233,662 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1092,191,718 - 92,232,645 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01091,953,470 - 91,995,414 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41093,312,405 - 93,354,229 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11093,326,247 - 93,368,673 (+)NCBI
Celera1087,735,518 - 87,777,693 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Crhr1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 61276
Created: 2001-01-05
Species: Rattus norvegicus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.