Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Hspb1 (heat shock protein family B (small) member 1) Rattus norvegicus
Symbol: Hspb1
Name: heat shock protein family B (small) member 1
Description: Exhibits ubiquitin binding activity. Involved in several processes, including cellular response to butyrate; cellular response to interleukin-11; and response to ischemia. Localizes to several cellular components, including myofibril; perikaryon; and postsynaptic density membrane. Biomarker of Alzheimer's disease and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2F; distal hereditary motor neuropathy type 2B; pancreatic cancer; and sarcoma. Orthologous to human HSPB1 (heat shock protein family B (small) member 1); PARTICIPATES IN Entamoebiasis pathway; mitogen activated protein kinase signaling pathway; vascular endothelial growth factor signaling pathway; INTERACTS WITH (+)-pilocarpine; (+)-schisandrin B; 1,3,5-trinitro-1,3,5-triazinane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: heat shock 27 kDa protein; heat shock 27 kDa protein 1; heat shock 27kDa protein 1; heat shock protein 1; heat shock protein B1; heat shock protein beta-1; HSP 27; Hsp25; Hsp27
Homo sapiens (human) : HSPB1 (heat shock protein family B (small) member 1)  HGNC  Alliance
Mus musculus (house mouse) : Hspb1 (heat shock protein 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hspb1 (heat shock protein family B (small) member 1)
Pan paniscus (bonobo/pygmy chimpanzee) : HSPB1 (heat shock protein family B (small) member 1)
Canis lupus familiaris (dog) : HSPB1 (heat shock protein family B (small) member 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hspb1 (heat shock protein family B (small) member 1)
Sus scrofa (pig) : HSPB1 (heat shock protein family B (small) member 1)
Heterocephalus glaber (naked mole-rat) : Hspb1 (heat shock protein family B (small) member 1)
more info ...
Is Marker For: QTLs:   Btemp2  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01223,839,390 - 23,841,051 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1223,839,399 - 23,841,049 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01225,837,102 - 25,838,663 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41221,911,223 - 21,912,784 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11221,898,486 - 21,900,048 (-)NCBI
Celera1222,557,404 - 22,559,067 (-)NCBICelera
Cytogenetic Map12q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Hspb1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 61306
Created: 2001-01-05
Species: Rattus norvegicus
Last Modified: 2020-05-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.