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Gene: Ncf1 (neutrophil cytosolic factor 1) Rattus norvegicus
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Symbol: Ncf1
Name: neutrophil cytosolic factor 1
Description: Contributes to superoxide-generating NADPH oxidase activity. Involved in apoptotic process and respiratory burst. Localizes to several cellular components, including the NADPH oxidase complex; cytoplasm; and neuronal cell body. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome; autosomal recessive chronic granulomatous disease cytochrome b-positive type I; and chronic granulomatous disease. Orthologous to several human genes including NCF1 (neutrophil cytosolic factor 1); PARTICIPATES IN chemokine mediated signaling pathway; Fc gamma receptor mediated signaling pathway; Leishmaniasis pathway; INTERACTS WITH (+)-catechin; (R)-lipoic acid; 11-deoxycorticosterone.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Ncf-1; neutrophil cytosol factor 1; p47phox; phagocyte oxidase 47 kDa; phagocyte oxidase, 47 kDa
Orthologs:
Homo sapiens (human) : NCF1 (neutrophil cytosolic factor 1)  HGNC  Alliance
Mus musculus (house mouse) : Ncf1 (neutrophil cytosolic factor 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ncf1 (neutrophil cytosolic factor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NCF1 (neutrophil cytosolic factor 1)
Canis lupus familiaris (dog) : NCF1 (neutrophil cytosolic factor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ncf1 (neutrophil cytosolic factor 1)
Sus scrofa (pig) : NCF1 (neutrophil cytosolic factor 1)
more info ...
Is Marker For: Strains:   LEW/Mol   LEW/Ztm  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01225,497,104 - 25,506,300 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01227,505,793 - 27,514,989 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41223,578,097 - 23,587,292 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11223,441,312 - 23,450,507 (+)NCBI
Celera1224,246,402 - 24,255,599 (+)NCBICelera
Cytogenetic Map12q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Ncf1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 61307
Created: 2001-01-05
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.