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Gene: Ncf1 (neutrophil cytosolic factor 1) Rattus norvegicus
Symbol: Ncf1
Name: neutrophil cytosolic factor 1
CRRD ID: 61307
Description: Contributes to superoxide-generating NAD(P)H oxidase activity. Involved in apoptotic process and respiratory burst. Localizes to several cellular components, including NADPH oxidase complex; neuronal cell body; and rough endoplasmic reticulum. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome; autosomal recessive chronic granulomatous disease cytochrome b-positive type I; and chronic granulomatous disease. Orthologous to several human genes including NCF1 (neutrophil cytosolic factor 1); PARTICIPATES IN chemokine mediated signaling pathway; Fc gamma receptor mediated signaling pathway; Leishmaniasis pathway; INTERACTS WITH (+)-catechin; (R)-lipoic acid; 11-deoxycorticosterone.
Type: protein-coding
Also known as: Ncf-1; neutrophil cytosol factor 1; p47phox; phagocyte oxidase 47 kDa; phagocyte oxidase, 47 kDa
Homo sapiens (human) : NCF1 (neutrophil cytosolic factor 1)  HGNC  Alliance
Mus musculus (house mouse) : Ncf1 (neutrophil cytosolic factor 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ncf1 (neutrophil cytosolic factor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NCF1 (neutrophil cytosolic factor 1)
Canis lupus familiaris (dog) : NCF1 (neutrophil cytosolic factor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ncf1 (neutrophil cytosolic factor 1)
Sus scrofa (pig) : NCF1 (neutrophil cytosolic factor 1)
Chlorocebus sabaeus (African green monkey) : NCF1 (neutrophil cytosolic factor 1)
Heterocephalus glaber (naked mole-rat) : Ncf1 (neutrophil cytosolic factor 1)
more info ...
Is Marker For: Strains:   LEW/Mol   LEW/Ztm  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01225,497,104 - 25,506,300 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1225,497,104 - 25,506,300 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01227,505,793 - 27,514,989 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41223,578,097 - 23,587,292 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11223,441,312 - 23,450,507 (+)NCBI
Celera1224,246,402 - 24,255,599 (+)NCBICelera
Cytogenetic Map12q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Ncf1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 61307
Created: 2001-01-05
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.