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Gene: Timp2 (TIMP metallopeptidase inhibitor 2) Rattus norvegicus
Symbol: Timp2
Name: TIMP metallopeptidase inhibitor 2
Description: Exhibits integrin binding activity and metalloendopeptidase inhibitor activity. Involved in several processes, including nervous system development; positive regulation of adenylate cyclase activity; and regulation of intracellular signal transduction. Localizes to several cellular components, including cell surface; growth cone; and neuronal cell body. Used to study portal hypertension. Biomarker of cardiomyopathy; congestive heart failure; and intracranial aneurysm. Human ortholog(s) of this gene implicated in Moyamoya disease. Orthologous to human TIMP2 (TIMP metallopeptidase inhibitor 2); INTERACTS WITH (+)-pilocarpine; (R)-noradrenaline; 1,3,5-trinitro-1,3,5-triazinane.
Type: protein-coding
Also known as: metalloproteinase inhibitor 2; MGC105282; TIMP-2; tissue inhibitor of metalloproteinase 2; tissue inhibitor of metalloproteinases 2
Homo sapiens (human) : TIMP2 (TIMP metallopeptidase inhibitor 2)  HGNC  Alliance
Mus musculus (house mouse) : Timp2 (tissue inhibitor of metalloproteinase 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Timp2 (TIMP metallopeptidase inhibitor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : TIMP2 (TIMP metallopeptidase inhibitor 2)
Canis lupus familiaris (dog) : TIMP2 (TIMP metallopeptidase inhibitor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Timp2 (TIMP metallopeptidase inhibitor 2)
Sus scrofa (pig) : TIMP2 (TIMP metallopeptidase inhibitor 2)
Chlorocebus sabaeus (African green monkey) : TIMP2 (TIMP metallopeptidase inhibitor 2)
Heterocephalus glaber (naked mole-rat) : Timp2 (TIMP metallopeptidase inhibitor 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.010107,338,465 - 107,386,072 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10107,338,465 - 107,386,072 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010106,973,463 - 107,021,070 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410108,310,473 - 108,358,821 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.110108,324,976 - 108,373,325 (-)NCBI
Celera10102,103,187 - 102,150,797 (-)NCBICelera
Cytogenetic Map10q32.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Timp2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 61312
Created: 2001-01-05
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.