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Gene: Timp2 (TIMP metallopeptidase inhibitor 2) Rattus norvegicus
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Symbol: Timp2
Name: TIMP metallopeptidase inhibitor 2
Description: Exhibits integrin binding activity and metalloendopeptidase inhibitor activity. Involved in several processes, including aging; nervous system development; and regulation of intracellular signal transduction. Localizes to several cellular components, including the extracellular space; growth cone; and neuronal cell body. Used to study portal hypertension. Biomarker of cardiomyopathy; congestive heart failure; and intracranial aneurysm. Human ortholog(s) of this gene implicated in Moyamoya disease. Orthologous to human TIMP2 (TIMP metallopeptidase inhibitor 2); INTERACTS WITH (+)-pilocarpine; (R)-noradrenaline; (RS)-amphetamine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: metalloproteinase inhibitor 2; MGC105282; TIMP-2; tissue inhibitor of metalloproteinase 2; tissue inhibitor of metalloproteinases 2
Orthologs:
Homo sapiens (human) : TIMP2 (TIMP metallopeptidase inhibitor 2)  HGNC  Alliance
Mus musculus (house mouse) : Timp2 (tissue inhibitor of metalloproteinase 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Timp2 (TIMP metallopeptidase inhibitor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : TIMP2 (TIMP metallopeptidase inhibitor 2)
Canis lupus familiaris (dog) : TIMP2 (TIMP metallopeptidase inhibitor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Timp2 (TIMP metallopeptidase inhibitor 2)
Sus scrofa (pig) : TIMP2 (TIMP metallopeptidase inhibitor 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.010107,338,465 - 107,386,072 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.010106,973,463 - 107,021,070 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410108,310,473 - 108,358,821 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.110108,324,976 - 108,373,325 (-)NCBI
Celera10102,103,187 - 102,150,797 (-)NCBICelera
Cytogenetic Map10q32.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Timp2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 61312
Created: 2001-01-05
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.