Gene: Prkn (parkin RBR E3 ubiquitin protein ligase) Rattus norvegicus
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Symbol: Prkn
Name: parkin RBR E3 ubiquitin protein ligase
Description: Exhibits protein kinase binding activity; involved in several processes, including cellular response to amino acid stimulus, modulation of chemical synaptic transmission, and negative regulation of cell death; localizes to several cellular components, including the cytoplasm, intracellular organelle, and membrane raft; predicted to colocalize with the LUBAC complex and mitochondrion-derived vesicle; used to study Parkinson's disease; biomarker of type 2 diabetes mellitus; orthologous to human PRKN (parkin RBR E3 ubiquitin protein ligase); PARTICIPATES IN altered mitochondrial autophagy pathway; mitochondrial autophagy pathway; Parkinson's disease pathway; INTERACTS WITH 6-propyl-2-thiouracil; ammonium chloride; androgen antagonist.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: E3 ubiquitin-protein ligase parkin; Park; Park2; parkin; parkin RBR E3 ubiquitin protein ligase 2; parkin variant SV5DEL; Parkinson disease (autosomal recessive, juvenile) 2, parkin; parkinson protein 2, E3 ubiquitin protein ligase
Orthologs:
Homo sapiens (human) : PRKN (parkin RBR E3 ubiquitin protein ligase)  HGNC  Alliance
Mus musculus (house mouse) : Prkn (parkin RBR E3 ubiquitin protein ligase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Prkn (parkin RBR E3 ubiquitin protein ligase)
Pan paniscus (bonobo/pygmy chimpanzee) : PRKN (parkin RBR E3 ubiquitin protein ligase)
Canis lupus familiaris (dog) : PRKN (parkin RBR E3 ubiquitin protein ligase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Prkn (parkin RBR E3 ubiquitin protein ligase)
Sus scrofa (pig) : PRKN (parkin RBR E3 ubiquitin protein ligase)
more info ...
Allele / Splice: Prknem1Sage  
Genetic Models: LE-Prknem1Sage-/- LE-Prknem1Sage
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0148,880,015 - 50,069,998 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0149,684,308 - 50,875,397 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4143,151,265 - 44,374,470 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1143,154,209 - 44,377,415 (-)NCBI
Celera144,478,407 - 45,666,902 (-)NCBICelera
Cytogenetic Map1q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models

Sequence

Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Prkn
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 61797
Created: 2001-04-11
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.