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Gene: Htr2a (5-hydroxytryptamine receptor 2A) Rattus norvegicus
Symbol: Htr2a
Name: 5-hydroxytryptamine receptor 2A
Description: Exhibits G protein-coupled serotonin receptor activity; G-protein alpha-subunit binding activity; and serotonin binding activity. Involved in several processes, including detection of stimulus involved in sensory perception of pain; modulation of chemical synaptic transmission; and regulation of blood vessel diameter. Localizes to several cellular components, including cell body fiber; dendritic shaft; and integral component of synaptic membrane. Used to study congestive heart failure; hyperglycemia; and pancreatitis. Biomarker of bladder neck obstruction and schizophrenia. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; anorexia nervosa; major depressive disorder; obesity; and obsessive-compulsive disorder. Orthologous to human HTR2A (5-hydroxytryptamine receptor 2A); PARTICIPATES IN calcium/calcium-mediated signaling pathway; INTERACTS WITH (R,R)-tramadol; (S)-nicotine; 1-bromopropane.
Type: protein-coding
Also known as: 5-HT-2; 5-HT-2A; 5-HT2A; 5-hydroxytryptamine (serotonin) receptor 2A; 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled; 5Ht-2; serotonin 5HT-2 receptor; serotonin 5HT-2 receptor gene; serotonin receptor 2A
Homo sapiens (human) : HTR2A (5-hydroxytryptamine receptor 2A)  HGNC  Alliance
Mus musculus (house mouse) : Htr2a (5-hydroxytryptamine (serotonin) receptor 2A)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Htr2a (5-hydroxytryptamine receptor 2A)
Pan paniscus (bonobo/pygmy chimpanzee) : HTR2A (5-hydroxytryptamine receptor 2A)
Canis lupus familiaris (dog) : HTR2A (5-hydroxytryptamine receptor 2A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Htr2a (5-hydroxytryptamine receptor 2A)
Sus scrofa (pig) : HTR2A (5-hydroxytryptamine receptor 2A)
Chlorocebus sabaeus (African green monkey) : HTR2A (5-hydroxytryptamine receptor 2A)
Heterocephalus glaber (naked mole-rat) : Htr2a (5-hydroxytryptamine receptor 2A)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01556,666,152 - 56,732,469 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1556,666,012 - 56,735,382 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01560,388,557 - 60,454,874 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41555,463,743 - 55,532,293 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11555,479,522 - 55,548,073NCBI
Celera1549,584,210 - 49,652,169 (+)NCBICelera
Cytogenetic Map15q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Htr2a
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 61800
Created: 2001-04-11
Species: Rattus norvegicus
Last Modified: 2020-05-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.