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Gene: Map2k2 (mitogen activated protein kinase kinase 2) Rattus norvegicus
Symbol: Map2k2
Name: mitogen activated protein kinase kinase 2
Description: Exhibits ATP binding activity and MAP kinase kinase activity. Involved in negative regulation of gene expression and protein phosphorylation. Localizes to cell cortex and cytosol. Human ortholog(s) of this gene implicated in cardiofaciocutaneous syndrome 4 and small intestine adenocarcinoma. Orthologous to human MAP2K2 (mitogen-activated protein kinase kinase 2); PARTICIPATES IN the extracellular signal-regulated Raf/Mek/Erk signaling pathway; adenosine signaling pathway; ceramide signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
Also known as: dual specificity mitogen-activated protein kinase kinase 2; ERK activator kinase 2; MAP kinase kinase 2; MAPK/ERK kinase 2; MAPKK 2; MEK 2; MEK2; Prkmk2
Homo sapiens (human) : MAP2K2 (mitogen-activated protein kinase kinase 2)  HGNC  Alliance
Mus musculus (house mouse) : Map2k2 (mitogen-activated protein kinase kinase 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Map2k2 (mitogen-activated protein kinase kinase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : LOC100977025 (dual specificity mitogen-activated protein kinase kinase 2)
Canis lupus familiaris (dog) : MAP2K2 (mitogen-activated protein kinase kinase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Map2k2 (mitogen-activated protein kinase kinase 2)
Sus scrofa (pig) : MAP2K2 (mitogen-activated protein kinase kinase 2)
Chlorocebus sabaeus (African green monkey) : MAP2K2 (mitogen-activated protein kinase kinase 2)
Heterocephalus glaber (naked mole-rat) : Map2k2 (mitogen-activated protein kinase kinase 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0711,458,971 - 11,478,520 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,458,967 - 11,478,489 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0711,626,294 - 11,645,884 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4710,074,654 - 10,094,003 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1710,074,657 - 10,094,003 (-)NCBI
Celera76,778,257 - 6,797,606 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Map2k2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 61888
Created: 2001-04-11
Species: Rattus norvegicus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.