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Gene: Mefv (MEFV innate immuity regulator, pyrin) Rattus norvegicus
Symbol: Mefv
Name: MEFV innate immuity regulator, pyrin
Description: Predicted to have actin binding activity; identical protein binding activity; and ubiquitin protein ligase activity. Involved in response to lipopolysaccharide and response to silicon dioxide. Predicted to localize to cytosol; microtubule associated complex; and nucleoplasm. Human ortholog(s) of this gene implicated in Henoch-Schoenlein purpura; asthma; familial Mediterranean fever; hematologic cancer (multiple); and lung disease. Orthologous to human MEFV (MEFV innate immuity regulator, pyrin); PARTICIPATES IN NOD-like receptor signaling pathway; INTERACTS WITH 2,4,6-trinitrotoluene; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
Also known as: LOC102552366; marenostrin; Mediterranean fever; MEFV, pyrin innate immunity regulator; pyrin; uncharacterized LOC102552366
Homo sapiens (human) : MEFV (MEFV innate immuity regulator, pyrin)  HGNC  Alliance
Mus musculus (house mouse) : Mefv (Mediterranean fever)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mefv (MEFV innate immuity regulator, pyrin)
Pan paniscus (bonobo/pygmy chimpanzee) : MEFV (MEFV innate immuity regulator, pyrin)
Canis lupus familiaris (dog) : MEFV (MEFV innate immuity regulator, pyrin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mefv (MEFV innate immuity regulator, pyrin)
Sus scrofa (pig) : MEFV (MEFV innate immuity regulator, pyrin)
Chlorocebus sabaeus (African green monkey) : MEFV (MEFV innate immuity regulator, pyrin)
Heterocephalus glaber (naked mole-rat) : Mefv (MEFV innate immuity regulator, pyrin)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01012,045,813 - 12,056,229 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1012,046,541 - 12,056,311 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01010,804,440 - 10,813,964 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41012,059,821 - 12,069,345 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11012,059,820 - 12,069,345 (+)NCBI
Celera1010,738,861 - 10,748,385 (+)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Mefv
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 61889
Created: 2001-04-11
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.